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Abstract:
BACKGROUND:Growth differentiation factor 11 (GDF11), a secreted member of the TGF-β superfamily, has recently been suggested as an anti-aging factor that declines with age in the bloodstream, and restoration of the youthful level by administration of its recombinant protein could reverse age-related dysfunctions. However, its effects on titanium implant osseointegration and mandibular bone during aging remain unknown. METHODS:Two-month-old and 18-month-old C57BL male mice were given daily intraperitoneal injections of recombinant GDF11 (rGDF11) or vehicle for 6 weeks. Experimental titanium implants were inserted into femurs on the 4th week. Inhibition of GDF11 function was achieved by GDF11 antibody. Implant-bearing femurs were subjected to histomorphometric analysis and biomechanical evaluation. Mandibles were scanned with micro-CT and decalcified for histological measurements. RESULTS:In both young adult and aged mice, supraphysiologic GDF11 leads to a significantly decreased bone-implant-contact ratio (BIC) and peri-implant bone volume (BV/TV) at the histologic level and reduced resistance at the biomechanical level, indicating weakened implant fixation. Moreover, rGDF11 administration resulted in less trabecular bone volume and thinner cortical thickness in the mandible, which was further compromised in the old animals. In contrast, inhibition of GDF11 improved peri-implant bone healing in old mice. CONCLUSIONS:Rather than functioning as a rejuvenating factor, exogenous GDF11 negatively affects not only titanium implant healing but also mandibular bone in both young and old mice. In contrast, neutralization of endogenous GDF11 has positive effects on implant fixation in aged mice. Therefore, treatment aimed at elevating GDF11 activity should be cautiously reconsidered. This article is protected by copyright. All rights reserved.
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最新影响因子:4.494 | 期刊ISSN:0022-3492 | CiteScore:2.85 |
出版周期:Monthly | 是否OA:YES | 出版年份:0 |
自引率:11.00% | 研究方向:医学-牙科与口腔外科 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas. Manuscripts are accepted for consideration with the understanding that text, figures, photographs, and tables have not appeared in any other publication, except as an abstract prepared and published in conjunction with a presentation by the author(s) at a scientific meeting, and that material has been submitted only to this journal.
牙周学杂志发表有关牙周科学和实践及相关领域的文章。接受稿件,但有一项谅解,即文本、图表、照片和表格从未出现在任何其他出版物中,除非作为摘要,并与作者在一次科学会议上的发言同时发表,而且材料仅提交给本杂志。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DENTISTRY, ORAL SURGERY & MEDICINE (牙科与口腔外科) 2区 |
9/91 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
159 | 148 | 11 |
引文计数(2018)
文献(2015-2017)
1864次引用
655篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Dentistry
小类(学科):Periodontics
|
#3/11
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