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Abstract:
BACKGROUND:The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats. METHODS:A total of thirty-two female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to defect creation. Bilateral OVX was performed in all test groups, and a sham operation was performed in the control group (n = 8). Drill-hole defects (1.5 mm diameter, 2 mm length) were created on both sides of the maxilla. All rats were euthanized 2 and 4 weeks after the surgery. Microcomputed tomographic, histological and histomorphometric analyses and in vitro experiments were performed. RESULTS:The 4M group showed significantly less new bone formation and a lower bone mineral density than the other groups in the microcomputed tomographic analysis. The histomorphometric analysis also revealed that the 4M group showed significantly less new bone formation than the control and 2M groups. The rats in the 4M group showed significantly higher alkaline phosphatase (ALP) expression levels and a larger number of calcified nodules than rats in the other groups, whereas osteoclastic activity was significantly lower in the 4M group than in the other groups. CONCLUSIONS:The critical time for impairment of alveolar bone regeneration was 4 months after OVX in rats. This article is protected by copyright. All rights reserved.
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最新影响因子:4.494 | 期刊ISSN:0022-3492 | CiteScore:2.85 |
出版周期:Monthly | 是否OA:YES | 出版年份:0 |
自引率:11.00% | 研究方向:医学-牙科与口腔外科 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas. Manuscripts are accepted for consideration with the understanding that text, figures, photographs, and tables have not appeared in any other publication, except as an abstract prepared and published in conjunction with a presentation by the author(s) at a scientific meeting, and that material has been submitted only to this journal.
牙周学杂志发表有关牙周科学和实践及相关领域的文章。接受稿件,但有一项谅解,即文本、图表、照片和表格从未出现在任何其他出版物中,除非作为摘要,并与作者在一次科学会议上的发言同时发表,而且材料仅提交给本杂志。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DENTISTRY, ORAL SURGERY & MEDICINE (牙科与口腔外科) 2区 |
9/91 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
159 | 148 | 11 |
引文计数(2018)
文献(2015-2017)
1864次引用
655篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Dentistry
小类(学科):Periodontics
|
#3/11
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