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Abstract:
Background Indoleamine 2,3-dioxygenase (IDO1) is an enzyme that acts as an immunomodulatory molecule. It is found in several types of cancer where it seems to be associated with tumor escape due to its immunosuppressive mechanisms. However, the role of IDO1 expression in prostate cancer (PC) is unclear. The aim of our study was to evaluate the expression of IDO1 in localized PC and to correlate with the classic prognostic factor and recurrence after surgical treatment. Methods We retrospectively evaluated surgical specimens from 111 patients with localized PC, who underwent radical prostatectomy. Recurrence was defined as a prostate specific antigen (PSA) level exceeding 0.2 ng/mL postoperatively, and the follow-up was 123 months. IDO1 expression was evaluated by immunohistochemistry in 72 cases of which 42 (58%) had biochemical recurrence. Results Lower IDO1 expression was associated with higher Gleason score ( p = 0.022) and PSA levels ( p = 0.042). The multivariate analyses revealed that the loss of IDO1 and higher PSA were independently associated with biochemical recurrence. The chance of recurrence was increased by 85% in patients with lower IDO1 [OR = 0.15; p = 0.009 CI 95% (0.038–0.633)] and increased by 5.5 times in patients with higher PSA [OR = 5.51; p = 0.012 CI 95% (1.435–21.21)]. The recurrence-free survival curve also demonstrates that lower IDO1 was associated with lower time to biochemical recurrence ( p = 0.0004). Conclusion The loss of IDO1 expression was associated with increased chance of biochemical recurrence, higher PSA, and a Gleason score in localized PC.
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最新影响因子:2.266 | 期刊ISSN:0301-1623 | CiteScore:1.57 |
出版周期:Quarterly | 是否OA:YES | 出版年份:1970 |
期刊官方网址:http://www.springer.com/medicine/nephrology/journal/11255
自引率:6.20% | 研究方向:医学-泌尿学与肾脏学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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International Urology and Nephrology publishes original papers on a broad range of topics in urology nephrology and andrology. The journal integrates papers originating from clinical practice. In addition to the regular papers book reviews also form an essential feature of the journal. International Urology and Nephrology is published at bimonthly intervals.
《国际泌尿外科和肾脏病学杂志》发表关于泌尿外科肾脏病学和男科学的广泛主题的原创论文.该期刊整合了源自临床实践的论文。除了常规论文外,书评也是该期刊的一个基本特征。国际泌尿外科和肾脏病学每两个月出版一次。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
UROLOGY & NEPHROLOGY (泌尿学与肾脏学) 4区 |
51/76 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
267 | 240 | 27 |
引文计数(2018)
文献(2015-2017)
1474次引用
938篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Nephrology
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#27/59
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2 |
大类(学科):Medicine
小类(学科):Urology
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#40/97
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研究方向:尿道下裂
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影响因子:1.375
ISSN:0021-8588
研究方向:AGRICULTURE, MULTIDISCIPLINARYMETEOROLOGY-METEOROL
影响因子:1
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研究方向:农林科学-农艺学
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ISSN:0168-1923
研究方向:农林科学-林学
影响因子:3.534
ISSN:1023-5809
研究方向:地学-地球化学与地球物理
影响因子:2.119
ISSN:1364-6826
研究方向:地学-地球化学与地球物理
影响因子:4.498
ISSN:1814-9324
研究方向:地学-气象与大气科学
影响因子:3.488
ISSN:2049-6060
研究方向:GEOSCIENCES, MULTIDISCIPLINARYMETEOROLOGY-METEOROL
影响因子:11.815
ISSN:1866-3508
研究方向:GEOSCIENCES, MULTIDISCIPLINARYMETEOROLOGY-METEOROL
影响因子:1.5
ISSN:2193-0856
研究方向:GEOSCIENCES, MULTIDISCIPLINARYMETEOROLOGY-METEOROL
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