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Abstract:
:Objectives: To investigate whether warm sterile water enhances the cytocidal effect of hypotonic shock on bladder cancer cells that show resistance to sterile water.Methods: Four bladder cancer cell lines of varying grades (T24, RT4, J82, and RT112) were exposed to sterile water, and morphological changes were closely observed under microscopy. Changes in cell membrane integrity and cell viability after water exposure were measured to determine the effects of water-induced hypotonic shock. Additionally, the effects of warm sterile water were analyzed.Results: T24, RT4, and J82 cells started swelling immediately upon exposure to water, followed by rupture within five minutes. RT112 cells demonstrated limited hypotonic swelling with significantly less cell rupture after 10 min. The percentages of viable cells at 10 min were 1.6 ± 0.8%, 3.5 ± 3.5%, 5.0 ± 3.2%, and 22.0 ± 10.3% for T24, RT4, J82, and RT112, respectively. The percentage of viable cells with 48 °C sterile water at one minute was 0% for RT112 cells.Conclusions: These findings support the efficacy of sterile water against bladder cancer cells and reveal that warm sterile water enhances the cytocidal effects of hypotonic shock, potentially avoiding the need for radical surgery.
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最新影响因子:1.899 | 期刊ISSN:2168-1805 | CiteScore:1.53 |
出版周期: | 是否OA:YES | 出版年份:0 |
自引率:8.70% | 研究方向:UROLOGY & NEPHROLOGY- |
出版地区:SWEDEN |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Scandinavian Journal of Urology is a journal for clinical urologists and publishes papers within all fields of clinical urology, with experimental papers related to clinical questions also invited. Important reports with great news value are published promptly. The journal presents a wide range of topics such as: Prostatic diseases Incontinence Nocturnal enuresis Kidney diseases
《斯堪的纳维亚泌尿学杂志》是一份临床泌尿学杂志,发表临床泌尿学各领域的论文,同时也邀请与临床问题相关的实验论文。具有重大新闻价值的重要报道及时发布。 该杂志提出了广泛的主题,如: 前列腺疾病 尿失禁 夜尿症 肾脏疾病
大类(学科) | 小类(学科) | 学科排名 |
医学 |
UROLOGY & NEPHROLOGY (泌尿学与肾脏学) 4区 |
52/76 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
76 | 70 | 6 |
引文计数(2018)
文献(2015-2017)
384次引用
251篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Nephrology
|
#29/59
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2 |
大类(学科):Medicine
小类(学科):Urology
|
#42/97
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发表一篇学和医学成像类SCI论文
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