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发表一篇学和医学成像类SCI论文
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Abstract:
PURPOSE:A pre-specified statistical model based on four kallikrein markers in blood, commercially available as the 4Kscore, has been shown to accurately detect high grade (>Grade Group 2) prostate cancer in men with moderately elevated PSA. We aimed to assess whether the model predicted prostate cancer metastasis or death in men not subject to PSA screening. MATERIALS AND METHODS:The cohort includes 43,692 unscreened prostate cancer-free men from a Swedish population-based cohort with low rates of PSA screening (Västerbotten Intervention Project). Using cryopreserved blood collected at ages 50 and 60 from men in this cohort, we analyzed the association between PSA and other kallikrein marker levels in blood and risk of prostate cancer metastasis or death. RESULTS:There were 308 with metastases, and 172 prostate cancer deaths. Baseline PSA was strongly associated with 20-year risk of prostate cancer death (c-index at age 50: 0.859, 95% CI 0.799-0.916; age 60: 0.840, 95% CI 0.799-0.878). Men aged 60 with PSA below median (<1.2 ng/ml) had 0.4% risk of prostate cancer death at 20 years. Among men with moderately elevated PSA (≥2.0 ng/ml), the 4Kscore markedly improved discrimination (c-index 0.767 vs. 0.828 and 0.774 vs. 0.862 in men 50 and 60). Long-term risk of prostate cancer death or metastasis in men with low 4Kscores was very low. CONCLUSION:Screening should focus on men in top PSA-quartile at age 60. Men with elevated PSA but a low 4Kscore can safely be monitored with repeated blood markers in place of immediate biopsy.
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最新影响因子:7.6 | 期刊ISSN:0022-5347 | CiteScore:1.67 |
出版周期:Monthly | 是否OA:YES | 出版年份:1917 |
期刊官方网址:http://www.jurology.com/
自引率:9.00% | 研究方向:医学-泌尿学与肾脏学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Official Journal of the American Urological Association (AUA), and the most widely read and highly cited journal in the field, The Journal of Urology® brings solid coverage of the clinically relevant content needed to stay at the forefront of the dynamic field of urology. This premier journal presents investigative studies on critical areas of research and practice, survey articles providing short condensations of the best and most important urology literature worldwide, and practice-oriented reports on significant clinical observations.The Journal of Urology® covers the wide scope of urology, including pediatric urology urologic oncology (cancer) renal transplantation male infertility calculi (urinary tract stones) female urology (urinary incontinence and pelvic outlet relaxation disorders) neurourology (voiding disorders, urodynamic evaluation of patients and erectile dysfunction or impotence). Members of the American Urological Association may access The Journal of Urology® online by logging in at AUA''s website. Nonmember personal subscribers may register and activate your subscription online at www.jurology.com. Authors and reviewers may submit and review manuscripts online. The editorial team at The Journal of Urology® is committed to providing authors a thorough review of their work in a quick timeframe. We return initial decisions within 3-4 weeks of receiving your submission, on average. If accepted, articles are posted online in fully citable form within about one week. Authors and reviewers may submit and review manuscripts online.
作为美国泌尿学协会(AUA)的官方期刊,也是该领域阅读最广泛、被引用最多的期刊,《泌尿学杂志》(Journal of Urology)对保持泌尿学动态领域前沿所需的临床相关内容进行了扎实的报道。这本卓越的杂志介绍了研究和实践的关键领域的调查研究,提供全世界最好和最重要的泌尿学文献的简短概括的调查文章,以及重要临床观察的实践导向报告。泌尿学杂志®涵盖泌尿学的广泛领域,包括 小儿泌尿外科 泌尿肿瘤(癌症) 肾移植 男性不育 结石(尿路结石) 女性泌尿科(尿失禁和盆腔出口松弛障碍) 神经泌尿学(排尿障碍、患者尿动力学评估和勃起功能障碍或阳痿)。 美国泌尿学协会的会员可以通过登录美国泌尿学协会的网站在线查阅泌尿学杂志。非会员的个人用户可在www.jurology.com网上注册并激活您的订阅。作者和审评员可在线提交和审查稿件。《泌尿学》杂志的编辑团队致力于在短时间内为作者提供对其工作的全面回顾。我们平均在收到你的呈件后3-4周内退回初步决定。如果被接受,文章将在一周内以完全可接受的形式在网上发布。作者和审评员可在线提交和审查稿件。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
UROLOGY & NEPHROLOGY(泌尿学和肾脏学) 2区 |
8/76 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
347 | 322 | 25 |
引文计数(2018)
文献(2015-2017)
6952次引用
4160篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Urology
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#35/97
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研究方向:前列腺 癌症 超声
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研究方向:医药科学 泌尿系统 原发性肾脏疾病
审稿时间: 1个月内
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研究方向:泌尿 肿瘤
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:尿道下裂
接受率: 比较困难(25%命中)
影响因子:2.762
ISSN:1869-0327
研究方向:MEDICAL INFORMATICS-
影响因子:3.298
ISSN:1472-6947
研究方向:医学-医学:信息
影响因子:2.749
ISSN:0272-989X
研究方向:医学-卫生保健
影响因子:4.947
ISSN:2291-5222
研究方向:-
影响因子:2.934
ISSN:1460-4582
研究方向:HEALTH CARE SCIENCES & SERVICES-MEDICAL INFORMATIC
影响因子:4.92
ISSN:0148-5598
研究方向:医学-卫生保健
影响因子:3.082
ISSN:1753-8157
研究方向:医学-卫生保健
影响因子:7.076
ISSN:1438-8871
研究方向:医学-卫生保健
影响因子:8
ISSN:1532-0464
研究方向:医学-计算机:跨学科应用
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