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Abstract:
BACKGROUND:To evaluate risk of prostate cancer biochemical recurrence following radical prostatectomy in men receiving versus not receiving testosterone therapy. PATIENTS AND METHODS:850 patients underwent radical prostatectomy by a single surgeon. All patients had preoperative testosterone and sex hormone binding globulin levels drawn; free testosterone was calculated prospectively.152 (18%) patients with low preoperative calculated free testosterone levels and delayed post-operative sexual function recovery were placed on testosterone therapy and proportionately matched to 419 control patients by pathologic Gleason Grade Group and stage. Rates and time to biochemical recurrence (two consecutive prostate specific antigen ≥ 0.2 ng/dl) were compared in univariate and multivariate regression; Cox regression was used to generate a survival function at the mean of covariates. RESULTS:Median follow-up was 3.5 years. There were no statistically significant differences in demographics or general health complications between groups. 11/152 (7.2%) and 53/419 (12.6%) patients experienced biochemical recurrence in the testosterone therapy versus control groups, respectively. In adjusted time to event analysis, testosterone therapy was an independent predictor of recurrence-free survival. After accounting for Gleason Grade Group, pathologic stage, preoperative prostate specific antigen, and calculated free testosterone, patients on testosterone therapy were approximately 54% less likely to recur (HR:0.54, 95%CI:0.292-0.997). In men destined to recur, testosterone therapy delayed time to recurrence by an average of 1.5 years. CONCLUSION:In our experience, testosterone replacement post-radical prostatectomy significantly reduced recurrence and delayed time to recurrence. There were no identifiable general health complications associated with testosterone therapy. These findings are hypothesis-generating and require confirmation with multi-centered, prospective randomized controlled trials.
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最新影响因子:5.969 | 期刊ISSN:1464-4096 | CiteScore:3.37 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1999 |
自引率:7.70% | 研究方向:医学-泌尿学与肾脏学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of the British Association of Urological Surgeons, the European Society of Paediatric Urology and the Societe Internationale d'Urologie BJU International is one of the most highly respected medical journals in the world. It presents unparalleled coverage of contemporary urological opinion, clinical reports and studies, innovations and developments.
《国际现代泌尿外科杂志》、《英国泌尿外科医师协会杂志》和《欧洲儿科泌尿学学会》是世界上最受尊敬的医学期刊之一。它提供了无与伦比的现代泌尿学观点,临床报告和研究,创新和发展的报道。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
UROLOGY & NEPHROLOGY (泌尿学与肾脏学) 2区 |
9/76 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
236 | 221 | 15 |
引文计数(2018)
文献(2015-2017)
3860次引用
1146篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Urology
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#5/97
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研究方向:泌尿外科 组织工程 膀胱修复
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研究方向:医药科学 泌尿系统 肾脏物质转运异常
审稿时间: 3个月内
影响因子:2.762
ISSN:1869-0327
研究方向:MEDICAL INFORMATICS-
影响因子:3.298
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研究方向:医学-医学:信息
影响因子:2.749
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研究方向:医学-卫生保健
影响因子:4.947
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研究方向:-
影响因子:2.934
ISSN:1460-4582
研究方向:HEALTH CARE SCIENCES & SERVICES-MEDICAL INFORMATIC
影响因子:4.92
ISSN:0148-5598
研究方向:医学-卫生保健
影响因子:3.082
ISSN:1753-8157
研究方向:医学-卫生保健
影响因子:7.076
ISSN:1438-8871
研究方向:医学-卫生保健
影响因子:8
ISSN:1532-0464
研究方向:医学-计算机:跨学科应用
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