发表一篇学和医学成像类SCI论文
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Abstract:
:Andiroba (Carapa guianensis Aubl) is an Amazonian plant whose oil has been widely used in traditional medicine for various purposes, including anti-inflammation. Research reports indicate that the oil can confer antitumor activity due to the presence of fatty acids, which can directly influence cell death mechanisms. Thus, andiroba oil (AO) has gained interest for its potential to be used in antineoplastic therapies. Here, we report an in vitro analysis of the cytotoxic and mutagenic potential of AO in the gastric cancer cell line, ACP02. Cell survival was assessed by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, differential staining with ethidium bromide and acridine orange assessed apoptosis-necrosis, and mutagenesis was assessed by the micronucleus test. The apolar oil was first diluted in 0.1% dimethyl sulfoxide (DMSO) and then further diluted to six concentrations (0.01, 0.1, 1, 10 and 100 μg/mL and 1 mg/mL) in RPMI medium. Controls included RPMI alone (negative control) and 0.1% DMSO diluted in medium (vehicle control). The MTT test showed that AO significantly reduced cell viability (P < .05) only when the highest tested concentration was applied for 48 hours. The apoptosis/necrosis test showed that the highest concentration of AO induced cell death by apoptosis at 24 and 48 hours. There was no statistically significant increase in the frequency of micronuclei. The ability of the AO to decrease the viability of ACP02 cells via apoptosis, without exerting mutagenic effects, suggests that the oil could be useful as an alternative therapeutic agent for primary tumors of stomach cancer.
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最新影响因子:3.628 | 期刊ISSN:0260-437X | CiteScore:3.25 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1981 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1263
自引率:6.60% | 研究方向:医学-毒理学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Applied Toxicology is devoted to publishing original research theoretical and literature reviews relating to the toxicity of drugs and chemicals to living systems at the molecular cellular tissue and target organ level. This also encompasses teratogenesis carcinogenesis mutagenesis mechanistic technology pharmacokinetics environmental toxicology and environmental health (including epidemiological studies) in addition to analytical and method development studies. Papers dealing with in vitro techniques and alternatives to the use of animals are encouraged. Experiments on animals should conform to prevailing national or international standards of welfare care and handling of animals (eg NUH guidelines). Investigations in human volunteers and patients must indicate that relevant ethical reviews and guidelines have been followed including obtaining informed consent. Papers must be of clear scientific value and contribute to knowledge and advancement in toxicology. All papers will be independently refereed. Contributions must be in English and not have been published elsewhere except as abstracts at scientific meetings. Review articles will be published and prior consultation with one of the editors is reommended. Review articles will also be refereed. Authors must agree not to communicate the same material for publication elsewhere.
《应用毒理学杂志》致力于在分子细胞组织和靶器官水平上发表有关药物和化学品对生物系统毒性的原始研究理论和文献综述。这也包括致畸、致癌、突变、机械技术、药代动力学、环境毒理学和环境卫生(包括流行病学研究)以及分析和方法开发研究。鼓励发表有关体外技术和动物使用替代方法的论文。动物实验应符合现行的国家或国际动物福利护理和处理标准(如NUH指南)。对人体志愿者和患者的调查必须表明,已经遵循了相关的伦理审查和指导方针,包括获得知情权。论文必须具有明确的科学价值,有助于毒理学的知识和进步。所有的论文都将被独立引用。稿件必须用英语书写,除作为科学会议的摘要外,不得在其他地方发表。将发表评论文章,并重新征求其中一位编辑的意见。评论文章也将被引用。作者必须同意不将同一材料传播到其他地方出版。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
TOXICOLOGY (毒理学) 3区 |
36/94 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
151 | 134 | 17 |
引文计数(2018)
文献(2015-2017)
1527次引用
470篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Toxicology
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研究方向:毒理
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研究方向:纳米毒理学
接受率: 中等(50%命中)
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研究方向:环境毒理学 斑马鱼
接受率: 中等(50%命中)
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研究方向:医药科学 预防医学 职业卫生
审稿时间: 6个月内
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研究方向:毒理
接受率: 一般容易(75%命中)
影响因子:2.748
ISSN:0026-1394
研究方向:工程技术-物理:应用
影响因子:1.843
ISSN:0034-6748
研究方向:工程技术-物理:应用
影响因子:2.442
ISSN:0895-3996
研究方向:工程技术-光学
影响因子:1.643
ISSN:1768-6733
研究方向:INSTRUMENTS & INSTRUMENTATION-MATERIALS SCIENCE, C
影响因子:1.446
ISSN:0970-3950
研究方向:工程技术-物理:应用
影响因子:8.307
ISSN:2040-3364
研究方向:CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTEC
影响因子:6.739
ISSN:2191-9089
研究方向:CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTEC
影响因子:2.838
ISSN:2076-3417
研究方向:CHEMISTRY, MULTIDISCIPLINARYMATERIALS SCIE-MATERIA
影响因子:2.024
ISSN:1745-8080
研究方向:工程技术-材料科学:综合
发表一篇学和医学成像类SCI论文
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