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Abstract:
:The Hippo pathway participates in development of numerous tumors through regulating tissue growth and cell fate. This study aimed to detect the association between the genetic variants in Hippo pathway genes and bladder cancer risk in a Chinese population. A case-control study of 580 cases and 1101 controls was performed to evaluate the association of single nucleotide polymorphisms (SNPs) in 39 candidate genes involved in the Hippo pathway with bladder cancer risk. A logistic regression model was used to assess the effects of SNPs on bladder cancer susceptibility. Candidate gene expression in human bladder cancer samples was detected using The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) datasets. We found that SNP rs755813 in WWC1 was significantly associated with a decreased risk of bladder cancer [odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.66-0.88, P = 3.63 × 10-4], which was more common in patients with low grade and non-muscle invasive tumors. Younger subjects (age ≤ 65) (OR = 0.70, 95% CI = 0.56-0.86), females (0.35, 0.23-0.52) and non-smokers (0.72, 0.58-0.88) showed a pronounced association between the rs755813 C allele and risk of bladder cancer by stratified analysis. The WWC1 was upregulated in bladder cancer tissues according to TCGA and GEO datasets. These findings indicated that genetic variant of WWC1 gene in Hippo signaling pathway contributes to the decreased risk of bladder cancer in the Chinese population and may have the protective effect against the development of bladder cancer.
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最新影响因子:6.168 | 期刊ISSN:0340-5761 | CiteScore:4.79 |
出版周期:Monthly | 是否OA:YES | 出版年份:1974 |
自引率:8.50% | 研究方向:医学-毒理学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Official journal of EUROTOX Edited on behalf of the Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie The provision of up-to-date information on the latest advances in toxicology is one of the main services that Archives of Toxicology offers its readers. Particular emphasis is laid on studies relating to defined effects of chemicals and mechanisms of toxicity including toxic activities at the molecular level in humans and experimental animals. Space is also devoted to new insights into analysis and toxicokinetics and to forensic toxicology. Review articles of general interest to toxicologists are a further important feature of the journal. Experimental and clinical data relating to toxicology can be submitted for publication in Archives of Toxicology as Original investigations Review articles Short communications or Letters to the editors
《欧洲毒理学》官方期刊是代表德国格列斯沙夫毛皮实验与毒理学研究所编辑的,提供毒理学最新进展的最新信息是毒理学档案为读者提供的主要服务之一。特别强调的是关于化学物质的明确影响和毒性机制的研究,包括在人类和实验动物分子一级的毒性活动。空间也致力于分析和毒物动力学和法医毒理学的新见解。毒理学家普遍感兴趣的综述文章是该杂志的另一个重要特征。与毒理学有关的实验和临床数据可作为原始调查综述文章提交毒理学档案,或作为简短的通信或信件发送给编辑
大类(学科) | 小类(学科) | 学科排名 |
医学 |
TOXICOLOGY (毒理学) 2区 |
7/94 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
257 | 212 | 45 |
引文计数(2018)
文献(2015-2017)
3002次引用
627篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Toxicology
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#9/111
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2 |
大类(学科):Environmental Science
小类(学科):Health, Toxicology and Mutagenesis
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#11/107
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研究方向:毒理
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研究方向:毒理
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研究方向:化学科学 环境化学 化学环境污染与健康
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研究方向:医药科学 预防医学 卫生毒理
审稿时间: 2个月内
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研究方向:毒理
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研究方向:医学-计算机:跨学科应用
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