
发表一篇学和医学成像类SCI论文
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Abstract:
:Bisphenol A (BPA) is commonly present in plastics used for food storage and preservation. The release of BPA from these products results in a permanent human exposition to BPA; however, the quality and quantity of BPA adverse effects remain a matter of controversy. The common presence of BPA in the human environment and the controversies concerning the relations of human exposition to BPA and cancer incidence justify the research on the interactions between BPA and pro-metastatic signaling in cancer cells. Here, we describe a novel BPA-reactive signaling axis that induces the epithelial-mesenchymal transition (EMT) in lung adenocarcinoma A549 cells. BPA exerted negligible effects on their properties in a wide range of concentrations (10 nM - 100 nM), whereas it considerably induced A549 invasiveness at high concentrations (10 μM). The BPA-induced EMT was illustrated by morphologic changes, E/N-cadherin switch and vimentin/Snail-1/connexin(Cx)43 up-regulation in A549 populations. It was followed by enhancement of A549 drug-resistance. Corresponding effects of BPA were observed in prostate cancer cell populations. Concomitantly, we observed increased levels and perinuclear accumulation of estrogen-related receptor gamma (ERRγ) in BPA-treated cells, its interactions with Cx43/Snail-1, and the corresponding effects of phenol red on A549 cells. Collectively, these data identify a novel, pro-metastatic Snail-1/Cx43/ERRγ signaling pathway. Its reactivity to BPA underlies the induction of cancer cells' invasiveness in the presence of high BPA concentrations in vitro. Thus, the chronic exposition of cancer cells to extrinsic and intrinsic BPA should be considered as a potential obstacle in a cancer therapy.
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最新影响因子:3.5 | 期刊ISSN:0887-2333 | CiteScore:3.37 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1987 |
期刊官方网址:http://www.elsevier.com/wps/find/journaldescription.cws_home/800/description
期刊投稿地址:http://ees.elsevier.com/tiv/
自引率:8.10% | 研究方向:医学-毒理学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
Toxicology in Vitro will publish original research papers and occasional reviews on the use of in vitro techniques for determining the toxic effects of chemicals and elucidating their mechanisms of action. The Journal will encourage the submission of studies which, by utilising cell or tissue culture, perfused organs, tissue slices, isolated cells or subcellular fractions, including enzymes and cell-receptors, investigate the mechanisms of toxic effects encountered in vivo or better characterize the relationship between in vitro and in vivo observations. All aspects of toxicology will be covered, including specific organ toxicity (eg neurotoxicity, nephrotoxicity), various toxic phenomena such as carcinogenesis or teratogenesis, and the development, characterization and validation of new in vitro models for the assessment and study of toxicity. The Journal's editorial policy will be firmly rooted in the need for high-quality science in support of health or safety decisions, and emphasis will be placed on results that facilitate evaluation of the hazard of chemicals to man and animals. NEW! Special rate for ESTIV members now available. For more information contact Dr. Diane Benford, ESTIV Secretary, Robens Institute, University of Surrey, Guildford, Surrey, GU2 5XH, U.K.; Tel: +44 1483 259 204; Fax: +44 1483 503 517; E-mail: d.benford@surrey.ac.uk or visit the ESTIV website at http://leden.tref.nl/ruttend/
体外毒理学将发表原始的研究论文和偶尔的评论,使用体外技术来确定化学品的毒性作用和阐明其作用机制。该杂志将鼓励提交研究报告,通过利用细胞或组织培养、灌注器官、组织切片、分离细胞或亚细胞组分(包括酶和细胞受体),研究体内遇到的毒性作用机制,或更好地描述体外和体内观察到的毒性作用之间的关系。离子。毒理学的各个方面都将涵盖,包括特定器官毒性(如神经毒性、肾毒性)、各种毒性现象(如致癌或致畸),以及毒性评估和研究的新体外模型的开发、表征和验证。期刊的编辑政策将牢牢扎根于对高质量科学的需求,以支持健康或安全决策,并将重点放在有助于评估化学品对人类和动物的危害的结果上。新成员现在可以享受特殊费率。欲了解更多信息,请联系Diane Benford博士,英国吉尔福德萨里大学罗本斯提夫研究所秘书;电话:+441483259204;传真:+441483503517;电子邮件:d.benford@surrey.ac.uk或访问http://leden.tref.nl/ruttend/网站
大类(学科) | 小类(学科) | 学科排名 |
医学 |
TOXICOLOGY(毒理学) 3区 |
32/94 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
246 | 240 | 6 |
引文计数(2018)
文献(2015-2017)
2254次引用
668篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Toxicology
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#19/111
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研究方向:毒理
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:毒理学
审稿时间: 3个月内 接受率: 一般容易(75%命中)
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接受率: 中等(50%命中)
影响因子:2.706
ISSN:1448-5028
研究方向:医学-传染病学
影响因子:5.078
ISSN:1087-2914
研究方向:医学-传染病学
影响因子:2.451
ISSN:0950-2688
研究方向:医学-传染病学
影响因子:3.926
ISSN:0195-6701
研究方向:医学-传染病学
影响因子:2.133
ISSN:1530-3667
研究方向:医学-传染病学
影响因子:2.918
ISSN:0196-6553
研究方向:医学-传染病学
影响因子:6.211
ISSN:1477-8939
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECT
影响因子:3.718
ISSN:1876-0341
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFEC
影响因子:3.254
ISSN:0899-823X
研究方向:医学-传染病学
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