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Objectives We assessed whether an association exists between myocardial oxygenation and myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM), using blood-oxygen-level-dependent (BOLD) T2* cardiac magnetic resonance imaging (T2*-CMR) and T1 mapping. Methods T1 mapping and T2*-CMR data were collected from 55 HCM patients using a 3-T MR and were prospectively analyzed. T2*-CMR was conducted using the black blood, breath-hold, multi-echo, and gradient echo sequence. Over 10 min, inhalation of oxygen at the flow rate of 10 L/min, T2* for mid-septum was measured following room-air and oxygen inhalation, and ΔT2* ratio (T2*oxy-T2*air/T2*air, %) was calculated. During pre- and post-gadolinium enhancement, native T1 (ms) and extracellular volume fractions (ECV, %) were calculated at sites same as the T2* measurement. Hypoxia was defined as the segment with an absolute value of the ΔT2* ratio ≥ 10%. Results ΔT2* ratio was significantly higher for segments with native T1 ≥ 1290 ms than those with native T1 < 1290 ms (21 ± 32% vs. 8 ± 6%, p = 0.005). ΔT2* ratio was also significantly higher for segments with ECV ≥ 28% than those with ECV < 28% (21 ± 32% vs. 8 ± 8%, p = 0.0003). ROC curve analysis revealed that ΔT2* ratio could detect segments with native T1 ≥ 1290 ms and ECV ≥ 28% and c-statistics of 0.72 and 0.79. According to the multivariate logistic regression analysis results, ECV is an independent factor in hypoxia ( odds ratio, 1.47; 95% confidence interval, 1.02–2.13; p < 0.05) . Conclusions Analysis of BOLD T2*-CMR and T1 mapping revealed that ECV is strongly associated with ΔT2* ratio, suggesting that the onset of myocardial fibrosis is related to hypoxia in HCM patients. Trial registration Our study was approved by the ethics committee of our institute (#4036, registered on 21 July 2016) Key Points • Analysis of ΔT2* ratio and ECV with BOLD-T2* and T1 mapping revealed a strong association between myocardial fibrosis and hypoxia in HCM patients.
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最新影响因子:7.034 | 期刊ISSN:0938-7994 | CiteScore:4.02 |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
期刊官方网址:http://www.springer.com/medicine/radiology/journal/330
期刊投稿地址:https://mc.manuscriptcentral.com/eurradiol?PROXY_TO_PAGE_NAME=&PRE_ACTION=&DISPLAY=&CURRENT_PAGE=LOG
自引率:13.30% | 研究方向:医学-核医学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Journal of the European Congress of Radiology (ECR) Official Organ of the European Association of Radiology (EAR) European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Head and Neck Radiology (ESHNR) European Society of Musculoskeletal Radiology (ESSR) European Society of Urogenital Radiology (ESUR) European Society of Thoracic Imaging (ESTI) European Radiology (ER) was founded as the European forum of radiology. It will continuously update the scientific knowledge in radiology by the publication of excellent original papers and state-of-the-art reviews written by leading radiologists. Through its link to the European Congress of Radiology (ECR) European Radiology will improve the communication with the other journals in the world. A thorough and competent refereeing procedure will serve the authors'''''''''''''''''''''''''''''''' need for critical feedback. A well balanced combination of review articles original work short communications from the congress and information on society matters makes ER an indispensable source for current information in this field. European Radiology will be subscribed by all participants of the European Congress of Radiology and will thus reach a regular audience of several thousand readers worldwide. Publishes original articles and state-of-the-art reviews by leading radiologists Offers a balanced combination of review articles, original work, short communications and information on society matters Journal of the European Society of Radiology (ESR) Official publication of a number of professional societies 100% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Free app available on iTunes and Google Play Store European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.
欧洲国会放射学杂志》(ECR)官方机构欧洲放射学协会(EAR)欧洲社会的胃肠道和腹部放射学(ESGAR)欧洲社会的头部和颈部放射学(ESHNR)欧洲社会的肌肉骨骼放射学(几)欧洲社会的泌尿生殖放射学(ESUR)欧洲社会的胸成像(ESTI)欧洲放射学(ER)成立的欧洲放射学论坛。它将不断更新放射学的科学知识,出版优秀的原创论文和一流的放射科医生写的最先进的评论。通过与欧洲放射学大会(ECR)的联系,欧洲放射学将改善与世界其他期刊的交流。一个全面和称职的评审程序将为作者提供批判性的反馈。将来自大会的评论文章、原创作品、简短的交流以及社会问题的信息很好地结合在一起,ER成为该领域当前信息不可或缺的来源。《欧洲放射学》将由欧洲放射学大会的所有与会者订阅,因此将面向全世界的几千名经常读者。 发表原创文章和先进的审查由领先的放射科医生 提供一个平衡的组合,审查文章,原创作品,简短的沟通和社会问题的信息 欧洲放射学会杂志(ESR) 若干专业学会的官方出版物 在接受调查的作者中,100%的人表示,他们肯定会在杂志上发表文章,或者可能会再次在杂志上发表文章 免费应用程序可在iTunes和谷歌播放商店 欧洲放射学(ER)不断更新放射学的科学知识,出版强有力的原创文章和先进的评论,由领先的放射学家撰写。综述文章、原始论文、来自欧洲放射学大会的简短通信和关于社会问题的信息的良好平衡的结合使ER成为该领域当前信息的一个不可或缺的来源。 这是欧洲放射学会的期刊,也是许多学会的官方期刊。 从2004年到2008年,《欧洲放射学补编》在其同伴《欧洲放射学补编》(ISSN 1613-3749)下出版。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING (核医学) 2区 |
20/129 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
576 | 571 | 5 |
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5400次引用
1342篇文献
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大类(学科):Medicine
小类(学科):Radiology, Nuclear Medicine and Imaging
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