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Abstract:
AIMS:Cardiovascular disease is a well-recognized cause of increased late morbidity and mortality among survivors of childhood cancer treated with anthracyclines. Co-administration of Dexrazoxane has been shown to significantly reduce short-term and mid-term cardiotoxicity. Aim of this study was to assess cardiac function in long-term (>10 years) survivors of childhood tumors treated with dexrazoxane/anthracycline association. METHODS AND RESULTS:Twenty cancer survivors previously treated with co-administration of anthracyclines-dexrazoxane for childhood renal tumors or sarcoma and a control group of 20 healthy subjects were enrolled in the study. Echocardiographic measurements included 3D left ventricular (LV) ejection fraction (LVEF) and LV and right ventricular (RV) global longitudinal strain (GLS). Among cancer survivors group the median age at diagnosis was 5 years (1-17) and they were evaluated at median follow-up time of 21.5 years (10-26). No evidence of cardiac toxicity, as defined by current guidelines, was reported in all survivors. No significant differences in standard and deformation imaging parameters were observed between survivors and controls (3D LVEF 58 ± 3% vs 60 ± 5% p = NS; LV GLS -21 ± 1% vs -21 ± 2% p = NS; RV GLS -23 ± 2% vs -23 ± 5% p = NS). No second tumor was registered in dexrazoxane-treated survivors. CONCLUSIONS:Our findings may support the role of dexrazoxane as a useful strategy for cardio-protection in children undergoing anthracycline based treatment. However, large randomized trials are needed to confirm the cardio-protective role of dexrazoxane in pediatric setting at long-term follow-up.
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最新影响因子:4.039 | 期刊ISSN:0167-5273 | CiteScore:1.76 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1981 |
期刊官方网址:http://www.elsevier.com/wps/find/journaldescription.cws_home/506041/description#description
期刊投稿地址:http://ees.elsevier.com/ijc/
自引率:8.80% | 研究方向:医学-心血管系统 |
出版地区:IRELAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The International Journal of Cardiology is devoted to cardiology in the broadest sense. Both basic research and clinical papers can be submitted. The journal serves the interest of both practicing clinicians and research workers.Editorials, Brief Reports and Review Articles covering recent developments are included. Controversial techniques, issues on health policy and social medicine are discussed and serve as useful tools for encouraging debate.International Journal of Cardiology has no page charges.A reduced personal subscription rate is available; please apply to the Publisher for more information.
《国际心脏病学杂志》在最广泛的意义上致力于心脏病学。基础研究和临床论文都可以提交。该杂志为临床医师和研究工作者提供了服务,包括社论、简要报告和评论文章。讨论有争议的技术、健康政策和社会医学问题,并作为鼓励辩论的有用工具。国际心脏病杂志不收取页面费用。可降低个人订阅率;请向出版商申请了解更多信息。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CARDIAC & CARDIOVASCULAR SYSTEMS (心脏和心血管系统) 3区 |
41/128 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
1199 | 1085 | 114 |
引文计数(2018)
文献(2015-2017)
11795次引用
6683篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Cardiology and Cardiovascular Medicine
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#113/327
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研究方向:医学 儿科
审稿时间: 6个月内
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研究方向:抗凝 抗栓 药物基因组学
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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审稿时间: 2个月内 接受率: 比较困难(25%命中)
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审稿时间: 3个月内
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审稿时间: 2个月内 接受率: 比较困难(25%命中)
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审稿时间: 3个月内 接受率: 中等(50%命中)
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影响因子:5.315
ISSN:0148-396X
研究方向:医学-临床神经学
影响因子:1.725
ISSN:0028-3770
研究方向:医学-临床神经学
影响因子:2.21
ISSN:1878-8750
研究方向:CLINICAL NEUROLOGY-SURGERY
影响因子:4.332
ISSN:1092-0684
研究方向:CLINICAL NEUROLOGY-SURGERY
影响因子:2.816
ISSN:0001-6268
研究方向:医学-临床神经学
影响因子:2.8
ISSN:0344-5607
研究方向:医学-临床神经学
影响因子:0.972
ISSN:1019-5149
研究方向:医学-临床神经学
影响因子:1.532
ISSN:0256-7040
研究方向:医学-临床神经学
影响因子:1.165
ISSN:1016-2291
研究方向:医学-临床神经学
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