HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.

Abstract:
AIMS:To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in embryonic and adult myocardium. METHODS AND RESULTS:Hand1 is expressed within the cardiomyocytes of the left ventricle (LV) and myocardial cuff between embryonic days (E) 9.5-13.5. Hand gene dosage plays an important role in ventricular morphology and the contribution of Hand1 to congenital heart defects requires further interrogation. Conditional ablation of Hand1 was carried out using either Nkx2.5 knockin Cre (Nkx2.5Cre) or α-myosin heavy chain Cre (αMhc-Cre) driver. Interrogation of transcriptome data via ingenuity pathway analysis reveals several gene regulatory pathways disrupted including translation and cardiac hypertrophy-related pathways. Embryo and adult hearts were subjected to histological, functional, and molecular analyses. Myocardial deletion of Hand1 results in morphological defects that include cardiac conduction system defects, survivable interventricular septal defects, and abnormal LV papillary muscles (PMs). Resulting Hand1 conditional mutants are born at Mendelian frequencies; but the morphological alterations acquired during cardiac development result in, the mice developing diastolic heart failure. CONCLUSION:Collectively, these data reveal that HAND1 contributes to the morphogenic patterning and maturation of cardiomyocytes during embryogenesis and although survivable, indicates a role for Hand1 within the developing conduction system and PM development.
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CARDIOVASCULAR RESEARCH
CARDIOVASC RES
最新影响因子:13.081 | 期刊ISSN:0008-6363 | CiteScore:5.19 |
出版周期:Monthly | 是否OA:YES | 出版年份:1967 |
期刊官方网址:http://cardiovascres.oxfordjournals.org/
期刊投稿地址:http://cardiovascres.oxfordjournals.org/for_authors/general.html#3. Manuscript submission
自引率:12.80% | 研究方向:医学-心血管系统 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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CARDIOVASCULAR RESEARCH 期刊简介
英文简介:
Cardiovascular Research is the International Basic Science Journal of the European Society of Cardiology. The Journal is concerned with both basic and clinical research in the field of cardiovascular physiology and pathophysiology. The Journal welcomes submission of papers both at the molecular, subcellular, cellular, organ and organism level, and of clinically oriented papers offering insight into (patho)physiological mechanisms.
中文简介:(来自Google、百度翻译)
《心血管研究》是欧洲心脏病学会的国际基础科学期刊。该杂志关注心血管生理学和病理生理学领域的基础和临床研究。该杂志欢迎提交分子、亚细胞、细胞、器官和有机体水平的论文,以及提供深入了解(patho)生理机制的临床导向论文。
CARDIOVASCULAR RESEARCH 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CARDIAC & CARDIOVASCULAR SYSTEMS(心脏和心血管系统) 2区 |
16/128 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
143 | 108 | 35 |
影响因子趋势图
CARDIOVASCULAR RESEARCH 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
3381次引用
651篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Physiology
|
#15/169
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|
|
2 |
大类(学科):Medicine
小类(学科):Cardiology and Cardiovascular Medicine
|
#11/327
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|
|
3 |
大类(学科):Medicine
小类(学科):Physiology (medical)
|
#7/97
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|
|
CiteScore趋势图
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最新评论(不代表本站观点)
-
liting7111
研究方向:医药科学 循环系统 血压调节异常 高血压病
审稿时间: 2个月内
投稿后,审稿大约两个月时间,现在越来越难投中了。2020-04-27 -
liting7111
研究方向:心血管 治疗 分子机制
接受率: 比较困难(25%命中)
刚投稿被拒稿一篇,8日提交稿件,11日收到邮件说细胞系不够明确,要求补充再提交,14日再提交后,12日被拒稿。没外审,主编认为文章试验方法欠缺。2020-04-16 -
liting7111
接受率: 比较困难(25%命中)
心脏病基础研究的权威杂志,要求故事完整,动物实验必须要有,文章创新性要高,语言要求也很严格。我投稿后大修一次,两个月补完实验,小修一次半个月就接收了。2020-03-07 -
liting7111
研究方向:心血管
杂志心血管临床研究可以投稿吗?2019-04-20
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