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Abstract:
:Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic metabolites; SNPs in aromatase and CYP1B1 have been associated with PAH. This suggests that estradiol metabolism could be altered in iPAH. This proof-of-concept study profiles estradiol and several metabolites of estradiol simultaneously in serum from iPAH patients and controls. We show that the estradiol and metabolite profile is altered in iPAH and that 16-hydroxyestrone and 16-hydroxyestradiol accumulate in iPAH patients with 16-hydroxyestrone levels relating to disease severity.
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自引率:10.50% | 研究方向:- |
出版地区: |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Pulmonary Circulation, is the official journal of the Pulmonary Vascular Research Institute. The journal is an open-access, international, peer-reviewed medical research journal focused on publishing original research, review articles, case reports, and guidelines articles exclusively in the fields of pulmonary circulation and pulmonary vascular disease. As an open-access title, Pulmonary Circulation aims to support the wide dissemination of knowledge to members of the field in order to improve patient care and treatment outcomes. The APC is $2,000 for Original Research Articles, unsolicited Reviews, Guidelines and Conference Reports. Case Reports, Letters to the Editor and Consensus reports will be charged at $1,000. There will be no charge for Editorials. The APC is payable upon acceptance and subject to VAT where applicable. Submissions will be handled simply and efficiently online through SAGE Track, powered by ScholarOne ManuscriptsTM. Submit today: https://mc.manuscriptcentral.com/pulmonarycirculation. Pulmonary Circulation has transferred to SAGE from the University of Chicago Press.
肺循环,是肺血管研究所的官方刊物。该杂志是一本开放的、国际性的、同行评审的医学研究杂志,专门发表肺循环和肺血管疾病领域的原始研究、综述文章、病例报告和指导性文章。 肺循环作为一个开放的访问标题,旨在支持向该领域的成员广泛传播知识,以提高患者的护理和治疗效果。 原始研究论文,主动提供的评论,指南和会议报告的APC为2000美元。案例报告,致编辑的信和共识报告将收取1000美元。社论将不收取任何费用。 APC在接受后支付,并在适用的情况下缴纳增值税。 通过由ScholarOne ManuscriptsTM提供支持的SAGE Track,可以在线简单有效地处理提交内容。立即提交:https://mc.manuscriptcentral.com/pulmonarycirculation。 肺循环已从芝加哥大学出版社转移到Sage。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CARDIAC & CARDIOVASCULAR SYSTEMS (心脏和心血管系统) 3区 RESPIRATORY SYSTEM (呼吸系统) 4区 |
64/128 38/60 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
106 | 88 | 18 |
引文计数(2018)
文献(2015-2017)
577次引用
245篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Pulmonary and Respiratory Medicine
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#37/132
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研究方向:医学 心脏 心血管系统
审稿时间: 3个月内
影响因子:2.438
ISSN:0261-1929
研究方向:农林科学-兽医学
影响因子:3.025
ISSN:1094-7159
研究方向:医学-临床神经学
影响因子:4.169
ISSN:0264-410X
研究方向:医学-免疫学
影响因子:17.579
ISSN:0022-1007
研究方向:医学-免疫学
影响因子:5.274
ISSN:0971-5916
研究方向:医学-免疫学
影响因子:4.061
ISSN:2314-6745
研究方向:ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EX
影响因子:2.976
ISSN:0914-8779
研究方向:医学-内分泌学与代谢
影响因子:4.75
ISSN:0141-8955
研究方向:医学-内分泌学与代谢
影响因子:10.171
ISSN:1931-5244
研究方向:医学-医学:内科
Pulmonary Circulation 投稿经验
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