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Abstract:
BACKGROUND:Although respiratory muscle weakness (RMW) is known to predict prognosis in patients with heart failure with reduced ejection fraction (HFrEF), RMW prevalence and its prognosis in those with preserved ejection fraction (HFpEF) remain unknown. We aimed to investigate whether the RMW predicted mortality in HFpEF patients. METHODS:We conducted a single-centre observational study with consecutive 1023 heart failure patients (445 in HFrEF and 578 in HFpEF). Maximal inspiratory pressure (PImax) was measured to assess respiratory muscle strength at hospital discharge, and RMW was defined as PImax <70% of predicted value. Endpoint was all-cause mortality after hospital discharge, and we examined the influence of RMW on the endpoint. RESULTS:Over a median follow-up of 1.8 years, 134 patients (13.1%) died; of these 53 (11.9%) were in HFrEF and 81 (14.0%) in HFpEF. RMW was evident in 190 (42.7%) HFrEF and 226 (39.1%) HFpEF patients and was independently associated with all-cause mortality in both HFrEF (adjusted hazard ratio [HR]: 2.13, 95% confidence interval [CI]: 1.17-3.88) and HFpEF (adjusted HR: 2.85, 95% CI: 1.74-4.67) patients. Adding RMW to the multivariate logistic regression model significantly increased area under the receiver-operating characteristic curve (AUC) for all-cause mortality in HFpEF (AUC including RMW: 0.78, not including RMW: 0.74, P = 0.026) but not in HFrEF (AUC including RMW: 0.84, not including RMW: 0.82, P = 0.132). CONCLUSIONS:RMW was observed in 39% of HFpEF patients, which was independently associated with poor prognosis. The additive effect of RMW on prognosis was detected only in HFpEF but not in HFrEF.
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最新影响因子:4.582 | 期刊ISSN:0954-6111 | CiteScore:3.33 |
出版周期:Monthly | 是否OA:YES | 出版年份:1989 |
期刊官方网址:http://www.journals.elsevier.com/respiratory-medicine/
自引率:5.50% | 研究方向:医学-呼吸系统 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Respiratory Medicine aims to be the international forum for new information of relevance to the physician working in the field of respiratory disease. It publishes high quality, original, papers on the physiology, pathology, immunology, genetics and epidemiology of respiratory disease and therapeutic interventions. Editorials and Topical Reviews geared towards both higher training and continuous medical education courses are a feature of the journal. Respiratory Medicine is abstracted/indexed by: Current Contents/Life Sciences/Clinical Practice, Index Medicus, Excerpta Medica Science Citation Index and Current Awareness in Biological Sciences.
呼吸医学旨在成为与呼吸疾病领域的医生有关的新信息的国际论坛。出版高质量、原创、呼吸系统疾病的生理学、病理学、免疫学、遗传学和流行病学以及治疗干预方面的论文。针对高等教育和继续医学教育课程的社论和专题评论是该杂志的特色。呼吸医学的摘要/索引依据:当前内容/生命科学/临床实践、指标医学、摘录医学引文指数和当前生物科学意识。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CARDIAC & CARDIOVASCULAR SYSTEMS(心脏和心血管系统) 3区 RESPIRATORY SYSTEM(呼吸系统) 3区 |
48/128 21/60 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
232 | 192 | 40 |
引文计数(2018)
文献(2015-2017)
2240次引用
673篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Pulmonary and Respiratory Medicine
|
#21/132
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研究方向:copd
审稿时间: 3个月内 接受率: 比较困难(25%命中)
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研究方向:临床 基础
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:医学-胃肠肝病学
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