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Abstract:
OBJECTIVES:The optimal timing for delivery in non-severe late-preterm (34 + 0-36 + 6 weeks) preeclampsia (PE) is uncertain. It is attempted to reach term pregnancy safely but current clinical and analytical parameters fail to determine which cases will develop severe features that require preterm delivery. We aim to establish if angiogenic biomarkers may identify cases that would benefit from earlier delivery. STUDY DESIGN:Prospective case-control study of 96 women (n = 48 controls and n = 48 cases with PE) with maternal determinations of the sFlt-1/PlGF ratio between 34 + 0 and 36 + 6 weeks. The PE group was classified in two groups based on the need (n = 26) or not (n = 22) for preterm delivery due to criteria of severity. Diagnostic accuracy of these biomarkers for predicting preterm delivery for severe PE was evaluated. MAIN OUTCOME MEASURES:Women with PE showed higher median sFlt-1/PlGF ratio than controls (122 vs 5, p < 0.01) and lower PlGF MoM (0.7 vs 1.0, p < 0.01). However, these differences did not remain when both PE subgroups were compared. Diagnostic performance of the sFlt-1/PlGF ratio and PlGF at different cut-offs was poor for detecting PE requiring delivery before term. CONCLUSIONS:Angiogenic biomarkers are not useful to predict which late-preterm PE cases will develop severe features that require preterm delivery.
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最新影响因子:2.494 | 期刊ISSN:2210-7789 | CiteScore: |
出版周期: | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://www.pregnancyhypertension.org/
期刊投稿地址:http://www.evise.com/evise/faces/pages/navigation/NavController.jspx?JRNL_ACR=PREGHY
自引率:6.30% | 研究方向:OBSTETRICS & GYNECOLOGYPERIPHERAL VASCULAR-PERIPHE |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health aims to stimulate research in the field of hypertension in pregnancy, disseminate the useful results of such research, and advance education in the field.
妊娠高血压:一份国际妇女心血管健康杂志,旨在促进妊娠高血压领域的研究,传播这类研究的有益成果,促进该领域的教育。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY(产科医学和妇科医学) 4区 PERIPHERAL VASCULAR DISEASE(周围血管疾病) 4区 |
44/82 44/65 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
65 | 63 | 2 |
引文计数(2018)
文献(2015-2017)
次引用
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研究方向:医学 妇产科学
审稿时间: 3个月内
liting7111
研究方向:心血管
审稿时间: 3个月内 接受率: 一般容易(75%命中)
影响因子:5.311
ISSN:0017-8748
研究方向:医学-临床神经学
影响因子:6.74
ISSN:0013-9580
研究方向:医学-临床神经学
影响因子:11.8
ISSN:0028-3878
研究方向:医学-临床神经学
影响因子:5.486
ISSN:0213-4853
研究方向:医学-临床神经学
影响因子:1.902
ISSN:0268-7038
研究方向:医学-临床神经学
影响因子:1.524
ISSN:1074-7931
研究方向:医学-临床神经学
影响因子:2.903
ISSN:1471-2377
研究方向:医学-临床神经学
影响因子:0.735
ISSN:1319-6138
研究方向:医学-临床神经学
影响因子:0.302
ISSN:1823-6138
研究方向:CLINICAL NEUROLOGY-
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