
发表一篇学和医学成像类SCI论文
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Abstract:
OBJECTIVE:The objective of this study was to use high-throughput sequencing to describe the vaginal eukaryotic DNA virome in patients undergoing in vitro fertilisation (IVF) to examine associations between the vaginal virome, antibiotic exposure and IVF outcomes. DESIGN:Prospective exploratory study. SETTING:Single academic fertility centre. POPULATION:Subfertile women age 18-43 years undergoing their first IVF cycle with a fresh embryo transfer. METHODS:The primary exposure was prophylactic azithromycin or no azithromycin before IVF. A mid-vaginal swab was obtained at the time of embryo transfer for virome analysis. MAIN OUTCOME MEASURES:The primary outcomes compared between exposure groups were characteristics of vaginal virome and clinical pregnancy rates. Secondary outcomes were virome associations with number of oocytes retrieved, number of blastocysts and implantation rate. RESULTS:Twenty-six women contributed a vaginal swab before embryo transfer. There were no significant differences in IVF outcomes between azithromycin groups. There was no association between viral diversity and clinical pregnancy overall. A higher diversity of herpesviruses and α-papillomaviruses was observed in samples from the azithromycin-treated group compared with the no azithromycin group (P = 0.04). In women that received azithromycin, viral diversity was higher in the group that did not achieve clinical pregnancy compared with those who did (P = 0.06). CONCLUSIONS:We demonstrate that the vaginal eukaryotic virome in women undergoing IVF is associated with antibiotic exposure. Additionally, we demonstrate an inverse trend between viral diversity and pregnancy, with a higher number of viruses detected associated with failure to achieve clinical pregnancy in the azithromycin group. TWEETABLE ABSTRACT:Higher viral diversity is associated with prophylactic antibiotic exposure in subfertile women undergoing IVF.
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最新影响因子:7.331 | 期刊ISSN:1470-0328 | CiteScore:1.89 |
出版周期:Monthly | 是否OA:YES | 出版年份:2000 |
自引率:5.50% | 研究方向:医学-妇产科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The British Journal of Obstetrics and Gynaecology (BJOG) is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists. The Journal publishes original, peer reviewed work in all areas of obstetrics and gynaecology, including contraception, uro-gynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality of medical research in women''s health worldwide.
《英国妇产科杂志》(BJOG)是皇家妇产科学院拥有的独立编辑刊物。该杂志发表了最初的,同行评审的工作,在所有领域的产科和妇科,包括避孕,泌尿妇科,生育,肿瘤和临床实践。它的目标是在世界范围内出版关于妇女健康的最高质量的医学研究。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 2区 |
6/82 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
201 | 154 | 47 |
引文计数(2018)
文献(2015-2017)
2937次引用
1557篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
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研究方向:医药科学 生殖系统 围生医学 新生儿 分娩 产褥
审稿时间: 1个月内
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研究方向:妇产科
审稿时间: 6个月内 接受率: 比较困难(25%命中)
影响因子:0.753
ISSN:0534-0012
研究方向:AGRONOMY-GENETICS & HEREDITY
影响因子:1.282
ISSN:0037-5349
研究方向:农林科学-林学
影响因子:3.017
ISSN:1364-6745
研究方向:医学-临床神经学
影响因子:3.469
ISSN:1475-2875
研究方向:医学-寄生虫学
影响因子:0.735
ISSN:0972-9062
研究方向:INFECTIOUS DISEASES-PARASITOLOGY
影响因子:0.209
ISSN:0125-1562
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECT
影响因子:1.794
ISSN:0142-6338
研究方向:医学-热带医学
影响因子:0.828
ISSN:0049-4755
研究方向:医学-公共卫生、环境卫生与职业卫生
影响因子:3.918
ISSN:1360-2276
研究方向:医学-公共卫生、环境卫生与职业卫生
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BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 投稿经验
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