Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial.

Abstract:
OBJECTIVE:Women with pre-eclampsia have elevated circulating levels of soluble fms-like tyrosine kinase-1 (sFlt-1). Statins can reduce sFlt-1 from cultured cells and improve pregnancy outcome in animals with a pre-eclampsia-like syndrome. We investigated the effect of pravastatin on plasma sFlt-1 levels during pre-eclampsia. DESIGN:Blinded (clinician and participant), proof of principle, placebo-controlled trial. SETTING:Fifteen UK maternity units. POPULATION:We used a minimisation algorithm to assign 62 women with early-onset pre-eclampsia (24+0 -31+6 weeks of gestation) to receive pravastatin 40 mg daily (n = 30) or matched placebo (n = 32), from randomisation to childbirth. PRIMARY OUTCOME:Difference in mean plasma sFlt-1 levels over the first 3 days following randomisation. RESULTS:The difference in the mean maternal plasma sFlt-1 levels over the first 3 days after randomisation between the pravastatin (n = 27) and placebo (n = 29) groups was 292 pg/ml (95% CI -1175 to 592; P = 0.5), and over days 1-14 was 48 pg/ml (95% CI -1009 to 913; P = 0.9). Women who received pravastatin had a similar length of pregnancy following randomisation compared with those who received placebo (hazard ratio 0.84; 95% CI 0.50-1.40; P = 0.6). The median time from randomisation to childbirth was 9 days (interquartile range [IQR] 5-14 days) for the pravastatin group and 7 days (IQR 4-11 days) for the placebo group. There were three perinatal deaths in the placebo-treated group and no deaths or serious adverse events attributable to pravastatin. CONCLUSIONS:We found no evidence that pravastatin lowered maternal plasma sFlt-1 levels once early-onset pre-eclampsia had developed. Pravastatin appears to have no adverse perinatal effects. TWEETABLE ABSTRACT:Pravastatin does not improve maternal plasma sFlt-1 or placental growth factor levels following a diagnosis of early preterm pre-eclampsia #clinicaltrial finds.
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BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
BJOG-INT J OBSTET GY
最新影响因子:7.331 | 期刊ISSN:1470-0328 | CiteScore:1.89 |
出版周期:Monthly | 是否OA:YES | 出版年份:2000 |
自引率:5.50% | 研究方向:医学-妇产科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 期刊简介
英文简介:
The British Journal of Obstetrics and Gynaecology (BJOG) is an editorially independent publication owned by the Royal College of Obstetricians and Gynaecologists. The Journal publishes original, peer reviewed work in all areas of obstetrics and gynaecology, including contraception, uro-gynaecology, fertility, oncology and clinical practice. Its aim is to publish the highest quality of medical research in women''s health worldwide.
中文简介:(来自Google、百度翻译)
《英国妇产科杂志》(BJOG)是皇家妇产科学院拥有的独立编辑刊物。该杂志发表了最初的,同行评审的工作,在所有领域的产科和妇科,包括避孕,泌尿妇科,生育,肿瘤和临床实践。它的目标是在世界范围内出版关于妇女健康的最高质量的医学研究。
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY(产科医学和妇科医学) 2区 |
6/82 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
201 | 154 | 47 |
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BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
2937次引用
1557篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
|
#51/168
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CiteScore趋势图
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最新评论(不代表本站观点)
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liting7111
产前诊断文章投稿三天拒稿,很干脆,不耽误时间。2020-01-06 -
liting7111
研究方向:医药科学 生殖系统 围生医学 新生儿 分娩 产褥
审稿时间: 1个月内
审稿意见给的很详细,不过我投稿的文章跟一篇文献类似,影响到发表了。2019-12-11 -
liting7111
研究方向:妇产科
审稿时间: 6个月内 接受率: 比较困难(25%命中)
去年7月投稿,11月一审结束,12月初修回,12月中旬接受了。19号就能在pubmed上检索到。我们组去年投了四篇,接收一篇。如果拒稿一般一个半月就会有消息。2019-05-09
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