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Abstract:
:Objective: To compare pregnancy outcomes between pregnancies following day 2, day 3, and days 5/6 fresh embryo transfer (ET).Methods: A retrospective cohort study including all pregnancies following fresh IVF/intracytoplasmic sperm injection (ICSI) ET cycles performed between January 2014 and December 2015 at Fertility and In Vitro Fertilization (IVF) Unit of the tertiary Soroka University Medical Center. The study groups consisted of 48, 72, 120, and 144 hours embryos. Pregnancies were confirmed by a serum beta-human chorionic gonadotropin measurement. Data regarding patients' medical history, infertility workup, fertility treatment characteristics, and outcome, as well as obstetrical outcome, were collected from patients' medical records and IVF Laboratory database. Multiple regression models were constructed to control for confounders. Patients who underwent fertility preservation treatment, cycles of oocyte donation or in vitro maturation oocytes, and cases of preimplantation genetic testing were excluded.Results: A total of 534 pregnancies following fresh IVF/ICSI ET on day 2 (n = 189, 35.4%), day 3 (n = 200, 37.5%), and days 5 or 6 (n = 145, 27.2%) were included. Live birth rate demonstrated a linear association to the developmental stage at ET with the highest rates in blastocysts and gradually lower in day 3 and day 2 ET (79.2, 65.8, and 60.6%, respectively, p = .001). A positive linear association was also observed between ET age and clinical pregnancy rate (77.3, 87.5, and 90.3% for days 2, 3, and 5/6, respectively, p = .002), as well as with combined pregnancy complication rate (29, 37.3, and 43.3%, p = .026). However, using multivariate logistic regression model controlling for ET age, maternal age, smoking, obesity, initial HCG level and peak E2 level, live birth rate was comparable between the study groups regardless of ET age. Pregnancy complications were comparable between the groups; however, a composite pregnancy complications variable was higher in the blastocyst pregnancies compared to cleavage embryos pregnancies.Conclusions: The common approach of blastocyst transfer, as high quality of the embryo, has not proven beneficial in terms of live birth rate. Moreover, cleavage stage embryos were not associated with adverse perinatal outcomes. The current data suggest maternal age has an independent effect on live birth.
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最新影响因子:2.323 | 期刊ISSN:1476-7058 | CiteScore:N/A |
出版周期:Monthly | 是否OA:YES | 出版年份:2002 |
自引率:9.00% | 研究方向:医学-妇产科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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欧洲围产期医学协会、亚洲和大洋洲围产期协会和国际围产期产科医生协会的官方期刊
欧洲围产期医学协会、亚洲和大洋洲围产期协会和国际围产期产科医生协会的官方期刊
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 4区 |
62/82 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
539 | 498 | 41 |
引文计数(2018)
文献(2015-2017)
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序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
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研究方向:胎儿医学
审稿时间: 3个月内 接受率: 一般容易(75%命中)
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研究方向:meta分析
审稿时间: 6个月内 接受率: 一般容易(75%命中)
影响因子:0.753
ISSN:0534-0012
研究方向:AGRONOMY-GENETICS & HEREDITY
影响因子:1.282
ISSN:0037-5349
研究方向:农林科学-林学
影响因子:3.017
ISSN:1364-6745
研究方向:医学-临床神经学
影响因子:3.469
ISSN:1475-2875
研究方向:医学-寄生虫学
影响因子:0.735
ISSN:0972-9062
研究方向:INFECTIOUS DISEASES-PARASITOLOGY
影响因子:0.209
ISSN:0125-1562
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECT
影响因子:1.794
ISSN:0142-6338
研究方向:医学-热带医学
影响因子:0.828
ISSN:0049-4755
研究方向:医学-公共卫生、环境卫生与职业卫生
影响因子:3.918
ISSN:1360-2276
研究方向:医学-公共卫生、环境卫生与职业卫生
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