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Mainstreamed genetic testing in ovarian cancer: patient experience of the testing process.
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Abstract:
OBJECTIVE:Pathogenic BRCA variants account for 5.8-24.8% of ovarian cancers. The identification of such a variant can have a significant impact on the affected individual and their relatives, determining eligibility for targeted therapies, predicting treatment response, and granting access to disease prevention strategies. Cancer services are responding to the increased demand for genetic testing with the introduction of mainstreamed genetic testing via oncology clinics. This study aimed to evaluate patient experience of the mainstreamed genetic testing pathway at a tertiary referral center in London, UK. METHODS:Study participants were patients diagnosed with high-grade non-mucinous ovarian cancer, tested via a mainstreamed genetic testing pathway at the tertiary referral center between February 2015 and June 2017. Eligible participants were invited to complete the retrospective study questionnaire. Five quantitative measures with additional free-text items were used to evaluate the patient experience of mainstreamed genetic testing. RESULTS:The tertiary referral center tested 170 ovarian cancer patients. Twenty-three pathogenic BRCA mutations were identified (23/170, 13.5%). One-hundred and six patients (106/170, 62.4%) met the study inclusion criteria. Twenty-nine of those invited to participate (29/106, 27.4%) returned the retrospective study questionnaire. Pathogenic BRCA1/2 variants were identified within four respondents (4/29, 13.8%). Motivations for genetic testing related to improved medical management, and the ability to provide relatives with genetic information. Participants did not appear to be adversely affected by result disclosure post-mainstreamed genetic testing. Two individuals with a pathogenic variant reported that the support provided by the tertiary referral center post-result disclosure could have been improved. CONCLUSION:Results of the current study support further psychosocial research into the expansion of the mainstreamed genetic testing pathway. The results, although promising, have also highlighted the importance of genetic awareness within the multi-disciplinary team and the provision of timely psychological support from genetic specialists.
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
INT J GYNECOL CANCER
| 最新影响因子：4.661 | 期刊ISSN：1048-891X | CiteScore：2.31 |
| 出版周期：Monthly | 是否OA：YES | 出版年份：1991 |
| 自引率：9.00% | 研究方向：医学-妇产科学 |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 期刊简介
英文简介：
Official Journal of the International Gynecologic Cancer Society. International Journal of Gynecological Cancer presents papers from throughout the global community of researchers covering many topics including: basic science; epidemiology; diagnostic techniques; surgery; radiotherapy; chemotherapy; pathology; experimental studies The Journal allows you to call on a roster of international experts for the latest research, advice, and knowledge in order to provide the best treatment for your patients.
中文简介：（来自Google、百度翻译）
国际妇科癌症学会官方期刊。《国际妇科癌症杂志》发表了来自全球研究人员的论文，涵盖许多主题，包括:基础科学;流行病学;诊断技术;手术;放射治疗;化疗;病理学;《实验研究》杂志允许您向国际专家咨询最新的研究、建议和知识，以便为您的患者提供最佳的治疗。Official Journal of the International Gynecologic Cancer Society. International Journal of Gynecological Cancer presents papers from throughout the global community of researchers covering many topics including: basic science; epidemiology; diagnostic techniques; surgery; radiotherapy; chemotherapy; pathology; experimental studies The Journal allows you to call on a roster of international experts for the latest research, advice, and knowledge in order to provide the best treatment for your patients.
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 3区 ONCOLOGY (肿瘤学) 4区 |
35/82 167/223 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 277 | 253 | 24 |
总被引频次：6622
特征因子：0.009840
影响因子趋势图
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 期刊CiteScore评价数据
最新CiteScore值
2.31
=
引文计数(2018)
文献(2015-2017)
=
1899次引用
821篇文献
文献总数（2014-2016）：821
被引比率：70%
SJR：0.98
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：1.005
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Medicine
小类(学科)：Oncology
|
#144/325
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|
|
| 2 |
大类(学科)：Medicine
小类(学科)：Obstetrics and Gynecology
|
#34/168
点击查看排名表
|
|
CiteScore趋势图
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最新评论(不代表本站观点)
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liting7111
研究方向：妇产科
2月19日投稿，等待了两个月询问编辑，编辑说还在找审稿人，5月3日状态更新，6月1号回复说又找到两位审稿人，我已经和主编联系过了，正在考虑是否转投其他杂志。2020-05-26 -
liting7111
研究方向：肿瘤
online速度有点慢！2020-04-26 -
liting7111
请问大家这杂志收case吗？有人投成功过吗？2020-03-22 -
liting7111
研究方向：妇产科 宫颈癌
接受率： 一般容易（75%命中）
2月初投稿，2月中旬under review，3月19号通知接收，没要求revision2019-12-04 -
liting7111
我在5月23日投稿，一周过去还没给稿号，大家都是多久拿到稿号的？我投其他杂志都没那么久！2019-08-15 -
liting7111
杂志是否需要版面费？2019-03-18
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