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Hyperglycosylated human chorionic gonadotropin as a predictor of ongoing pregnancy.
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Abstract:
BACKGROUND:Hyperglycosylated human chorionic gonadotropin, the predominant human chorionic gonadotropin variant secreted following implantation, is associated with trophoblast invasion. OBJECTIVE:To determine whether the initial serum hyperglycosylated human chorionic gonadotropin differs between ongoing and failed pregnancies, and to compare it to total serum human chorionic gonadotropin as a predictor of ongoing pregnancy. MATERIALS AND METHODS:Women undergoing fresh/frozen in vitro fertilization cycles at a university-based infertility clinic with an autologous day 5 single embryo transfer resulting in serum human chorionic gonadotropin >3 mIU/mL (n = 115) were included. Human chorionic gonadotropin was measured 11 days after embryo transfer in a single laboratory (coefficient of variation <6%). Surplus frozen serum (-80C) was shipped to Quest Laboratories for measurement of hyperglycosylated human chorionic gonadotropin (coefficient of variation <9.1%). Linear regression analyses adjusted for oocyte age a priori were used to compare human chorionic gonadotropin and hyperglycosylated human chorionic gonadotropin in ongoing pregnancies (>8 weeks of gestation) and failed pregnancies (clinical pregnancy loss, biochemical and ectopic pregnancies). RESULTS:A total of 85 pregnancies (73.9%) were ongoing. Hyperglycosylated human chorionic gonadotropin and human chorionic gonadotropin values were highly correlated (Pearson correlation coefficient 92.14, P < .0001), and mean values of both were positively correlated with blastocyst expansion score (P value test for trend < .0004). Mean human chorionic gonadotropin and hyperglycosylated human chorionic gonadotropin were significantly higher in ongoing vs failed pregnancies. Among ongoing pregnancies vs clinical losses, mean hyperglycosylated human chorionic gonadotropin, but not human chorionic gonadotropin, was significantly higher (19.0 vs 12.2 ng/mL, β -8.1, 95% confidence interval -13.0 to -3.2), and hyperglycosylated human chorionic gonadotropin comprised a higher proportion of total human chorionic gonadotropin (4.6% vs 4.1%; risk ratio, 0.79; 95% confidence interval, 0.66-0.94). CONCLUSION:Measured 11 days after single blastocyst transfer, hyperglycosylated human chorionic gonadotropin and human chorionic gonadotropin values were highly correlated, but only mean hyperglycosylated human chorionic gonadotropin and its ratio to total human chorionic gonadotropin were significantly higher in ongoing pregnancies vs clinical pregnancy losses. Further evaluation of hyperglycosylated human chorionic gonadotropin, including in multiple embryo transfers and multiple pregnancy, and using serial measurements, is required.
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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
AM J OBSTET GYNECOL
| 最新影响因子：10.693 | 期刊ISSN：0002-9378 | CiteScore：3.5 |
| 出版周期：Monthly | 是否OA：YES | 出版年份：1920 |
期刊官方网址：http://www.ajog.org/
| 自引率：11.90% | 研究方向：医学-妇产科学 |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 期刊简介
英文简介：
The American Journal of Obstetrics and Gynecology, “The Gray Journal”, covers the full spectrum of Obstetrics and Gynecology. The aim of the Journal is to publish original research (clinical and translational), reviews, opinions, video clips, podcasts and interviews that will have an impact on the understanding of health and disease and that has the potential to change the practice of women's health care. An important focus is the diagnosis, treatment, prediction and prevention of obstetrical and gynecological disorders. The Journal also publishes work on the biology of reproduction, and content which provides insight into the physiology and mechanisms of obstetrical and gynecological diseases.
中文简介：（来自Google、百度翻译）
美国妇产科杂志，“灰色杂志”，涵盖了妇产科的所有领域。该杂志的目的是发表原创研究(临床和翻译)、评论、意见、视频剪辑、播客和访谈，这些将对健康和疾病的理解产生影响，并有可能改变妇女保健的做法。妇产科疾病的诊断、治疗、预测和预防是一个重要的研究重点。该杂志还出版了生殖生物学方面的著作，内容涉及妇产科疾病的生理学和机制。 好处的作者
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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 1区 |
2/82 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 343 | 310 | 33 |
总被引频次：40864
特征因子：0.049260
影响因子趋势图
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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 期刊CiteScore评价数据
最新CiteScore值
3.5
=
引文计数(2018)
文献(2015-2017)
=
6254次引用
1788篇文献
文献总数（2014-2016）：1788
被引比率：70%
SJR：2.7
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：1.811
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Medicine
小类(学科)：Obstetrics and Gynecology
|
#5/168
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CiteScore趋势图
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liting7111
研究方向：妇产科
写了篇流行病方向文章，同门的投稿都是一个月就审回，我两个月才审回，5个审稿人给了拒绝，但是可以修改后重投，大修再投两个月还是被拒了。2020-06-11 -
liting7111
研究方向：妇产科
审稿时间： 2个月内
9月1号投稿，10月7号通知拒稿。审稿速度块，审稿人意见也很有价值。2020-04-12 -
liting7111
研究方向：妇科肿瘤
审稿时间： 2个月内 接受率： 比较困难（25%命中）
审稿一个半月拒稿，不怎么好中，接受率20%2020-03-18 -
liting7111
研究方向：临床 流行病学 妇科学
审稿时间： 2个月内 接受率： 比较困难（25%命中）
投稿后竟然看不到状态，不过两个月后拒稿了，审稿人意见挺不错的。2020-02-15 -
liting7111
杂志收不收综述文章？2019-08-22 -
liting7111
研究方向：妇产科
审稿时间： 2个月内 接受率： 比较困难（25%命中）
之前投稿gynecology oncology被拒，按照意见修改后去年12月投稿，两个月修回，小修之后四个月接收，4月底在线，杂志还是偏临床。2019-05-12
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