发表一篇学和医学成像类SCI论文
需要多少钱?
Abstract:
:The objective of this study was to determine the frequency of expression of GRP78 and BIK/NBK proteins, as well as to evaluate their correlation with prognostic factors for clinical use in patients with locally advanced breast cancer (LABC) or preoperative chemotherapy (PC). An observational, analytical and retrospective study that evaluated the expression of BIK/NBK and GRP78 by means of immunohistochemistry in paraffin-embedded tumour tissue samples obtained before the start of PC was executed. GRP78 was positive in 93.3% and BIK/NBK was positive in 40% of the samples analysed. Correlation of GRP78 expression with Ki67 expression (Rho = 0.732, p = .039), and of BIK/NBK expression with Ki67 expression (Rho = 0.777, p = .023) and number of residual lymph nodes (Rho = 0.619, p = .014) was observed. Given the correlation observed, association studies of the expression of GRP78 and BIK/NBK with clinical and pathological response, recurrence and survival should be carried out in a greater number of patients with LABC or PC.Impact StatementWhat is already known on this subject? There are reports of the overexpression of GRP78 in various types of cancer cell lines and tumour biopsies, including breast cancer, with participation in resistance to adjuvant chemotherapeutic agents (topoisomerase inhibitors including Adriamycin). On the other hand, BIK/NBK has been observed expressed associated with poor outcomes in breast cancer. There are no studies of the expression of both biomarkers in patients with preoperative chemotherapy, including locally advanced breast cancer (LABC) or their correlation with prognosis markers of clinical use.What the results of this study add? We observed a correlation of higher expression percentage of GRP78 and BIK/NBK with higher expression of Ki67, a marker of poor prognosis in breast cancer, in addition to a significant correlation of higher percentage of BIK/NBK expression with a greater number of residual nodes in patients with LABC or PC.What the implications are of these findings for clinical practice and/or further research? There is a potential prognostic value of GRP78 and BIK/NBK in the pathological response that merits further study addressing their interaction with other proteins, their cellular location in relation to the clinical stages of breast cancer, and their association with prognosis (clinical and pathological response, recurrence, disease free period and survival) in a greater number of patients with LABC or PC.
展开更多
最新影响因子:1.226 | 期刊ISSN:0144-3615 | CiteScore:N/A |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1980 |
自引率:5.30% | 研究方向:医学-妇产科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
Journal of Obstetrics and Gynaecology represents an established forum for the entire field of obstetrics and gynaecology, publishing a broad range of original, peer-reviewed papers, from scientific and clinical research to reviews relevant to practice. It also includes occasional supplements on clinical symposia. The journal is read widely by trainees in our specialty and we acknowledge a major role in education in Obstetrics and Gynaecology. Past and present editors have recognized the difficulties that junior doctors encounter in achieving their first publications and spend time advising authors during their initial attempts at submission. The journal continues to attract a world-wide readership thanks to the emphasis on practical applicability and its excellent record of drawing on an international base of authors.
妇产科学杂志是妇产科学和妇产科学领域的一个成熟的论坛,出版了从科学和临床研究到与实践相关的评论等一系列原创的、经过同行评审的论文。它还包括临床研讨会上偶尔的补充。该杂志被我们专业的学员广泛阅读,我们承认在产科和妇科教育中发挥着重要作用。过去和现在的编辑都认识到初级医生在完成他们的第一份出版物时遇到的困难,并在他们最初投稿时花时间向作者提供建议。由于强调实用性和它在吸收国际作者方面的优秀记录,该杂志继续吸引着全世界的读者。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 4区 |
78/82 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
262 | 254 | 8 |
引文计数(2018)
文献(2015-2017)
N/A次引用
N/A篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
|
#0/168
点击查看排名表
|
|
推荐刊物均可到国家新闻出
版总署网站查询正刊
可签署保密协议 ,不透露任
何用户信息可跟踪进程,全程
协议
1对1服务,7x24小时在线
15年经验沉淀,实体公司
运营
liting7111
审稿时间: 12个月内 接受率: 中等(50%命中)
liting7111
审稿时间: 6个月内
影响因子:2.655
ISSN:1520-9512
研究方向:医学-呼吸系统
影响因子:3.427
ISSN:1027-3719
研究方向:医学-传染病学
影响因子:4.09
ISSN:8755-6863
研究方向:医学-呼吸系统
影响因子:5.526
ISSN:1526-0542
研究方向:医学-呼吸系统
影响因子:2.973
ISSN:1472-9792
研究方向:医学-呼吸系统
影响因子:3.289
ISSN:2055-1010
研究方向:PRIMARY HEALTH CARE-RESPIRATORY SYSTEM
影响因子:10.262
ISSN:0012-3692
研究方向:医学-呼吸系统
影响因子:2.339
ISSN:0020-1324
研究方向:医学-呼吸系统
影响因子:102.642
ISSN:2213-2600
研究方向:RESPIRATORY SYSTEM-RESPIRATORY SYSTEM
发表一篇学和医学成像类SCI论文
需要多少钱?
专注医学期刊服务15年
您好:请问您咨询什么等级的期刊?专注医学类期刊发表15年口碑企业,为您提供以下服务:
1.医学核心期刊发表-全流程服务
2.医学SCI期刊-全流程服务
3.论文投稿服务-快速报价
4.期刊推荐直至录用,不成功不收费
客服正在输入...
JOURNAL OF OBSTETRICS AND GYNAECOLOGY 投稿经验
(由下方点评分析获得,2人参与,16356人阅读)