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Abstract:
OBJECTIVE:To evaluate the influence of pessary visit intervals on development of vaginal epithelial abnormalities. METHODS:We conducted a randomized, noninferiority trial of office-based pessary care. Eligible participants were adult women wearing a ring, Gellhorn, or incontinence dish pessary to treat pelvic organ prolapse or incontinence or both. Patients were randomized 1:1 to routine pessary care (office visits every 12 weeks, "routine" arm) or to extended pessary care (office visits every 24 weeks, "extended" arm). The primary study outcome was rate of vaginal epithelial abnormalities (epithelial break or erosion) at the final study visit (48 weeks). The predetermined noninferiority margin was 7.5%. RESULTS:From January 2015 through June 2017, inclusive, 448 patients were screened and 130 were randomized, 64 to the routine arm and 66 to the extended arm. Baseline characteristics of the study arms were similar with the exception of pessary type, with ring pessary more common in the routine arm and Gellhorn pessary more common in the extended arm (P=.02). The rate of epithelial abnormalities at the final study visit (48 weeks) was 7.4% in the routine arm and 1.7% in the extended arm (difference, -5.7 percentage points; 95% CI -7.4 to -4), which met the criterion for noninferiority. Rates of all types of epithelial abnormalities did not differ between arms at any time point. Increasing duration of pessary use (P=.003) and history of prior epithelial abnormalities were associated with development of epithelial abnormalities (P=.01). Other than epithelial abnormalities, no adverse events related to pessary use occurred in either arm. CONCLUSION:In women who receive office-based pessary care and are using a ring, Gellhorn, or incontinence dish pessary, routine follow-up every 24 weeks is noninferior to every 12 weeks based on incidence of vaginal epithelial abnormalities. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, NCT02371083.
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最新影响因子:7.623 | 期刊ISSN:0029-7844 | CiteScore:3.21 |
出版周期:Monthly | 是否OA:YES | 出版年份:1953 |
期刊官方网址:http://journals.lww.com/greenjournal/pages/default.aspx
自引率:10.40% | 研究方向:医学-妇产科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Popularly known as "The Green Journal", Obstetrics & Gynecology publishes original articles and research studies on: scientific advances new medical and surgical techniques obstetric management clinical evaluation of drugs and instruments. In addition to its authoritative articles and studies, Obstetrics & Gynecology continues to feature the sections that obstetricians and gynecologists around the world have come to depend upon - After Office Hours, Case Reports, Instruments and Methods, Graduate Education, Editorials, and Letters.Obstetrics & Gynecology''s rigorous editorial policies ensure that all articles are of the highest quality and that they are published while current. These policies have made The Green Journal one of the most respected and most consulted journals in the world.Obstetrics & Gynecology is the most complete and reliable source of information on current developments in women''s health care.
妇产科学以“绿色期刊”著称,发表原创文章和研究成果:科学进步、新医学和外科技术、产科管理、临床评价药物和仪器。除了它的权威文章和研究,妇产科继续以产科医生和世界各地的妇科医生所依赖的部分为特色-下班时间,病例报告,仪器和方法,研究生教育,社论和信件。《妇产科》杂志严格的编辑政策确保了所有的文章都是高质量的,并且是最新的。这些政策使《绿色期刊》成为世界上最受尊重和咨询最多的期刊之一。妇产科学是关于当前妇女保健发展的最完整和可靠的信息来源。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 2区 |
5/82 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
337 | 324 | 13 |
引文计数(2018)
文献(2015-2017)
5265次引用
1638篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
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研究方向:临床 肿瘤 回顾性分析
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研究方向:医学-全科医学与补充医学
影响因子:0
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研究方向:ONCOLOGY-ENDOCRINOLOGY & METABOLISM
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