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Abstract:
OBJECTIVE:To evaluate whether abnormal plasma placental growth factor (PlGF) level is associated with adverse neonatal and maternal outcomes. METHODS:This was a secondary analysis of the Preeclampsia Triage by Rapid Assay Trial (PETRA), a prospective, multicenter, observational study that enrolled women with suspected preeclampsia. Our analysis included women age 18-45 years with a singleton pregnancy between 20 and 41 weeks of gestation. Plasma collected at enrollment was used for PlGF measurement. Abnormal PlGF was defined as low (100 pg/mL or less) or very low (less than 12 pg/mL). The primary outcomes were composite adverse neonatal and maternal outcomes. We used multivariable Poisson regression models to examine the association between PlGF and outcomes. RESULTS:Of 1,112 women who met the inclusion criteria, plasma PlGF was low in 742 (67%) and very low in 353 (32%). In the cohort, the overall rates of the composite adverse neonatal and maternal outcomes were 6.4% and 4.8%, respectively. Compared with normal PlGF (more than 100 pg/mL), low PlGF was significantly associated with an increased risk of the composite neonatal outcome (9.2% vs 0.8%; adjusted relative risk [aRR] 17.2, 95% CI 5.2-56.3), and the composite maternal outcome (6.2% vs 1.9%; aRR 3.6, 95% CI 1.7-8.0). Very low PlGF was also significantly associated with both neonatal and maternal outcomes. The sensitivity and specificity of low PlGF were 95.8% and 35.3%, respectively, for the composite neonatal outcome, and 86.8% and 34.3% for the composite maternal outcome. Although the positive predictive values were low (9.2% and 6.2%, respectively), the negative predictive value of low PlGF for neonatal and maternal outcomes was 99.2% and 98.1%, respectively. CONCLUSION:Among women being evaluated for preeclampsia, those with abnormal PlGF are significantly more likely to experience adverse neonatal and maternal outcomes. These outcomes occur infrequently when the PlGF is normal. These findings suggest that PlGF may be useful for risk stratification of women with suspected preeclampsia. FUNDING SOURCE:No funding was received for this study. The original PETRA study was supported by funding from Alere.
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最新影响因子:7.623 | 期刊ISSN:0029-7844 | CiteScore:3.21 |
出版周期:Monthly | 是否OA:YES | 出版年份:1953 |
期刊官方网址:http://journals.lww.com/greenjournal/pages/default.aspx
自引率:10.40% | 研究方向:医学-妇产科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Popularly known as "The Green Journal", Obstetrics & Gynecology publishes original articles and research studies on: scientific advances new medical and surgical techniques obstetric management clinical evaluation of drugs and instruments. In addition to its authoritative articles and studies, Obstetrics & Gynecology continues to feature the sections that obstetricians and gynecologists around the world have come to depend upon - After Office Hours, Case Reports, Instruments and Methods, Graduate Education, Editorials, and Letters.Obstetrics & Gynecology''s rigorous editorial policies ensure that all articles are of the highest quality and that they are published while current. These policies have made The Green Journal one of the most respected and most consulted journals in the world.Obstetrics & Gynecology is the most complete and reliable source of information on current developments in women''s health care.
妇产科学以“绿色期刊”著称,发表原创文章和研究成果:科学进步、新医学和外科技术、产科管理、临床评价药物和仪器。除了它的权威文章和研究,妇产科继续以产科医生和世界各地的妇科医生所依赖的部分为特色-下班时间,病例报告,仪器和方法,研究生教育,社论和信件。《妇产科》杂志严格的编辑政策确保了所有的文章都是高质量的,并且是最新的。这些政策使《绿色期刊》成为世界上最受尊重和咨询最多的期刊之一。妇产科学是关于当前妇女保健发展的最完整和可靠的信息来源。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 2区 |
5/82 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
337 | 324 | 13 |
引文计数(2018)
文献(2015-2017)
5265次引用
1638篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
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研究方向:妇产科
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研究方向:临床 肿瘤 回顾性分析
接受率: 非常困难(几乎不命中)s
影响因子:1
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影响因子:1.145
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研究方向:化学-化学综合
影响因子:4.036
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研究方向:chemical sciences-
影响因子:3.21
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研究方向:CHEMISTRY, MULTIDISCIPLINARY-
影响因子:2.63
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研究方向:CHEMISTRY, MULTIDISCIPLINARY-
影响因子:0.356
ISSN:0009-2770
研究方向:化学-化学综合
OBSTETRICS AND GYNECOLOGY 投稿经验
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