发表一篇学和医学成像类SCI论文
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Abstract:
Abnormal expression of miRNAs is closely related to the occurrence and development of tumors, and thus has become the most concerned biomolecule in the field of tumors. But so far, miRNAs that are truly recognized and studied for their function are only a small part, and their mechanism in tumors needs to be further studied. In this study, we identify that miR-3148 is downregulated in the development of cervical cancer. In cervical cancer cells, upregulated miR-3148 inhibits cell proliferation and promotes apoptosis, suggesting that miR-3148 acts as a tumor suppressor gene. Furthermore, we explored the mechanism of miR-3148 in cervical cancer cells from both transcriptional and post-transcriptional levels. Our research reveals that on the one hand, bromodomain containing 7 (BRD7) acts as a transcription factor to up-regulate the expression of miR-3148 at the transcriptional level; on the other hand, miR-3148 targets the 3′UTR of Wnt3a mRNA to inhibit Wnt3a expression at the post-transcriptional level, thereby suppressing Wnt3a/β-catenin signaling pathway and exerting its tumor suppressor role in cervical cancer. In conclusion, our study elucidates the mechanism of BRD7/miR-3148/Wnt3a/β-catenin pathway in cervical cancer and provides a new research direction for targeted therapy of cervical cancer.
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最新影响因子:2.924 | 期刊ISSN:1933-7191 | CiteScore:2.31 |
出版周期:Monthly | 是否OA:YES | 出版年份:2007 |
期刊官方网址:http://rsx.sagepub.com/
期刊投稿地址:https://uk.sagepub.com/en-gb/eur/reproductive-sciences/journal201848#submission-guidelines
自引率:11.30% | 研究方向:医学-妇产科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Reproductive Sciences (formerly known as the Journal of Gynecologic Investigation) has an impact factor of 2.887 and is ranked #8/57 in Obstetrics and Gynecology. Reproductive Sciences, formerly the Journal of the Society for Gynecologic Investigation (JSGI), is changing its name and expanding its focus to reflect the enormous changes in reproductive sciences and related sciences during the last decades. While continuing to publish the original, peer-reviewed, research and reviews that made JSGI one of the most highly ranked and highly cited publications in obstetrics and gynecology, Reproductive Sciences also will highlight translational research in the reproductive sciences and medicine. Its aim is to fulfill the need for a publication at the interface between basic and clinical research, especially for human studies. Reproductive Sciences will have a multi-discipline perspective, including all aspects of basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
生殖科学(原名《妇科调查杂志》)的影响因子为2.887,在产科和妇科中排名为8/57。生殖科学,以前是妇科研究学会(JSGI)的期刊,正在改变其名称,扩大其关注范围,以反映过去几十年中生殖科学和相关科学的巨大变化。虽然继续出版原著、同行评审、研究和评论,使JSGi成为产科和妇科中排名最高、引用率最高的出版物之一,但生殖科学也将突出生殖科学和医学中的转化研究。它的目的是满足在基础研究和临床研究,特别是人类研究之间的接口出版的需要。生殖科学将具有多学科视角,包括基础生殖生物学和医学、母胎医学、产科、妇科、生殖内分泌学、泌尿妇科、生育/不孕、胚胎学、妇科/生殖肿瘤学、发育生物学、干细胞研究、分子/细胞生物学及其他相关领域。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 3区 REPRODUCTIVE BIOLOGY (生殖生物学) 4区 |
27/82 15/29 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
173 | 146 | 27 |
引文计数(2018)
文献(2015-2017)
1303次引用
564篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
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#34/168
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研究方向:生殖医学
接受率: 中等(50%命中)
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审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:围产医学
接受率: 中等(50%命中)
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审稿时间: 3个月内 接受率: 中等(50%命中)
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审稿时间: 2个月内
影响因子:2.748
ISSN:0026-1394
研究方向:工程技术-物理:应用
影响因子:1.843
ISSN:0034-6748
研究方向:工程技术-物理:应用
影响因子:2.442
ISSN:0895-3996
研究方向:工程技术-光学
影响因子:1.643
ISSN:1768-6733
研究方向:INSTRUMENTS & INSTRUMENTATION-MATERIALS SCIENCE, C
影响因子:1.446
ISSN:0970-3950
研究方向:工程技术-物理:应用
影响因子:8.307
ISSN:2040-3364
研究方向:CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTEC
影响因子:6.739
ISSN:2191-9089
研究方向:CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTEC
影响因子:2.838
ISSN:2076-3417
研究方向:CHEMISTRY, MULTIDISCIPLINARYMATERIALS SCIE-MATERIA
影响因子:2.024
ISSN:1745-8080
研究方向:工程技术-材料科学:综合
发表一篇学和医学成像类SCI论文
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