
发表一篇学和医学成像类SCI论文
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Abstract:
:Preeclampsia (PE) is a disease unique to pregnancy and one of the leading causes of maternal and neonatal morbidity and mortality. Our previous study found that Lin28b, an RNA-binding protein stem cell factor, is down-expressed in the placenta of preeclampsia and significantly increases the invasion of HTR-8/SVneo cells in vitro. However, the mechanism of Lin28b's role is unclear. The purpose of this study is to investigate whether Lin28B affects the biological behavior and vascular development of trophoblast cells through miR-92b and downstream signaling pathway DKK1/Wnt/β-catenin. Our study demonstrated that Lin28B promotes trophoblast invasion through miR-92b in HTR-8 cells. Further experiments showed that microRNA-92b could negatively regulate DKK1 expression in placental trophoblasts, thereby inhibiting the activity of Wnt/beta-catenin signaling pathway, thereby inhibiting the migration and invasion of trophoblasts. Furthermore, we explored the expression of DKK1 and β-catenin in the placental tissues of preeclampsia patients and 20 healthy people. This study confirmed that Lin28 acts on DKK1 through miR-92b, which affects the expression of downstream Wnt/β-catenin, inhibits the invasion of trophoblast cells and the development of placental vasculature, and participates in the occurrence of PE.
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最新影响因子:2.924 | 期刊ISSN:1933-7191 | CiteScore:2.31 |
出版周期:Monthly | 是否OA:YES | 出版年份:2007 |
期刊官方网址:http://rsx.sagepub.com/
期刊投稿地址:https://uk.sagepub.com/en-gb/eur/reproductive-sciences/journal201848#submission-guidelines
自引率:11.30% | 研究方向:医学-妇产科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Reproductive Sciences (formerly known as the Journal of Gynecologic Investigation) has an impact factor of 2.887 and is ranked #8/57 in Obstetrics and Gynecology. Reproductive Sciences, formerly the Journal of the Society for Gynecologic Investigation (JSGI), is changing its name and expanding its focus to reflect the enormous changes in reproductive sciences and related sciences during the last decades. While continuing to publish the original, peer-reviewed, research and reviews that made JSGI one of the most highly ranked and highly cited publications in obstetrics and gynecology, Reproductive Sciences also will highlight translational research in the reproductive sciences and medicine. Its aim is to fulfill the need for a publication at the interface between basic and clinical research, especially for human studies. Reproductive Sciences will have a multi-discipline perspective, including all aspects of basic reproductive biology and medicine, maternal-fetal medicine, obstetrics, gynecology, reproductive endocrinology, urogynecology, fertility/infertility, embryology, gynecologic/reproductive oncology, developmental biology, stem cell research, molecular/cellular biology and other related fields.
生殖科学(原名《妇科调查杂志》)的影响因子为2.887,在产科和妇科中排名为8/57。生殖科学,以前是妇科研究学会(JSGI)的期刊,正在改变其名称,扩大其关注范围,以反映过去几十年中生殖科学和相关科学的巨大变化。虽然继续出版原著、同行评审、研究和评论,使JSGi成为产科和妇科中排名最高、引用率最高的出版物之一,但生殖科学也将突出生殖科学和医学中的转化研究。它的目的是满足在基础研究和临床研究,特别是人类研究之间的接口出版的需要。生殖科学将具有多学科视角,包括基础生殖生物学和医学、母胎医学、产科、妇科、生殖内分泌学、泌尿妇科、生育/不孕、胚胎学、妇科/生殖肿瘤学、发育生物学、干细胞研究、分子/细胞生物学及其他相关领域。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OBSTETRICS & GYNECOLOGY (妇产科学) 3区 REPRODUCTIVE BIOLOGY (生殖生物学) 4区 |
27/82 15/29 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
173 | 146 | 27 |
引文计数(2018)
文献(2015-2017)
1303次引用
564篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Obstetrics and Gynecology
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研究方向:生殖医学
接受率: 中等(50%命中)
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审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:围产医学
接受率: 中等(50%命中)
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审稿时间: 3个月内 接受率: 中等(50%命中)
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审稿时间: 2个月内
影响因子:1
ISSN:1758-1559
研究方向:农林科学-奶制品与动物科学
影响因子:1.656
ISSN:0009-4293
研究方向:化学-化学综合
影响因子:0.638
ISSN:0235-7216
研究方向:化学-化学综合
影响因子:0.354
ISSN:0001-9704
研究方向:化学-化学综合
影响因子:1.145
ISSN:0100-4042
研究方向:化学-化学综合
影响因子:4.036
ISSN:2046-2069
研究方向:chemical sciences-
影响因子:3.21
ISSN:2192-6506
研究方向:CHEMISTRY, MULTIDISCIPLINARY-
影响因子:2.63
ISSN:2191-1363
研究方向:CHEMISTRY, MULTIDISCIPLINARY-
影响因子:0.356
ISSN:0009-2770
研究方向:化学-化学综合
Reproductive Sciences 投稿经验
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