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Abstract:
:To investigate the association between visit-to-visit variability in blood pressure and the incidence of dementia and its subtypes in a general population, we conducted a population-based retrospective cohort study using the Korean National Health Insurance System database. We identified 7 844 814 subjects without a history of any dementia who underwent ≥3 health examinations from 2005 to 2012 in the Korean National Health Insurance System cohort. Blood pressure variability (BPV) was measured using the variability independent of the mean, coefficient of variation, and SD. During the median follow-up of 6.2 years, there were 200 574 cases of all-cause dementia (2.8%), 165 112 cases of Alzheimer's disease (2.1%), and 27 443 cases of vascular dementia (0.3%). There was a linear association between higher BPV and outcome measures. In the multivariable adjusted model, the hazard ratios and 95% CIs of all-cause dementia were 1.06 (1.04-1.07) for the highest quartile of variability independent of the mean of diastolic blood pressure only, 1.09 (1.08-1.11) for that of systolic blood pressure only, and 1.18 (1.16-1.19) for that of both systolic and diastolic blood pressure compared with subjects having no highest quartile for BPV. Consistent results were noted for Alzheimer's disease and vascular dementia using other indices of variability and in various sensitivity and subgroup analyses. BPV is an independent predictor for developing dementia and its subtypes. A dose-response relationship was noted between higher BPV and dementia incidence. Reducing BPV may be a target for preventing dementia in the general population.
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最新影响因子:9.897 | 期刊ISSN:0194-911X | CiteScore:5.34 |
出版周期:Monthly | 是否OA:YES | 出版年份:1979 |
期刊官方网址:http://hyper.ahajournals.org/
期刊投稿地址:http://hype-submit.aha-journals.org/cgi-bin/main.plex
自引率:9.70% | 研究方向:医学-外周血管病 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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This journal provides a forum for the presentation of scientific investigation of the highest quality in the broad field of blood pressure regulation and the pathophysiological mechanisms underlying hypertensive diseases.
这本杂志提供了一个论坛,介绍了在广泛的血压调节领域中最高质量的科学研究和高血压疾病的病理生理机制。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PERIPHERAL VASCULAR DISEASE(周围血管疾病) 1区 |
3/65 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
271 | 254 | 17 |
引文计数(2018)
文献(2015-2017)
6818次引用
1276篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Internal Medicine
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#6/121
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研究方向:医药科学 循环系统 血压调节异常 高血压病
审稿时间: 2个月内
liting7111
研究方向:高血压
接受率: 比较困难(25%命中)
liting7111
接受率: 比较困难(25%命中)
liting7111
研究方向:高血压
接受率: 比较困难(25%命中)
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研究方向:高血压 认知功能
接受率: 比较困难(25%命中)
liting7111
研究方向:高血压 心脏 心血管
接受率: 中等(50%命中)
影响因子:4.521
ISSN:1865-1674
研究方向:农林科学-传染病学
影响因子:1.943
ISSN:0165-2427
研究方向:农林科学-免疫学
影响因子:9.667
ISSN:0093-7355
研究方向:农林科学-兽医学
影响因子:0.408
ISSN:0263-841X
研究方向:农林科学-兽医学
影响因子:2.721
ISSN:0307-9457
研究方向:农林科学-兽医学
影响因子:0.214
ISSN:0969-1251
研究方向:农林科学-兽医学
影响因子:0.198
ISSN:0023-2076
研究方向:农林科学-兽医学
影响因子:0.274
ISSN:0177-7726
研究方向:农林科学-兽医学
影响因子:2.56
ISSN:0042-4900
研究方向:农林科学-兽医学
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