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Age-related structural alterations of skeletal muscles and associated capillaries.
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Abstract:
:Aging is associated with a progressive decline in muscle mass, strength, and quality. We have previously demonstrated the important role of the blood vasculature system in ultraviolet (UV) light-induced changes in skin and its molecular mechanisms. Whereas recent findings revealed structural alterations of the cutaneous vasculature in aged and photoaged human skin, structural changes of blood vessels in skeletal muscles with age have remained unclear. Although, facial skeletal muscles could be involved in skin-aging, here, we show-for the first time-that, in the lateral great muscle, the cross-sectional muscle fiber area and vessels size were decreased in older skin compared with that in younger skin. In the orbicularis oculi muscle, no significant interaction between age and the muscle fiber area was observed. However, a significantly decreased ratio of muscle area was indicated in older skin compared with that in younger skin. Interestingly, the pericyte-covered vessels ratio was decreased in older skin. Therefore, we found that the skeletal muscle capillary destabilizes with age. In summary, we revealed that the lateral great muscle and the orbicularis oculi muscle fibers become thinner with age due to the destabilization of skeletal muscle capillaries. Therapeutic targeting of muscle capillaries might affect the decline of skeletal muscles with age and could potentially regulate muscle/skin-aging.
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ANGIOGENESIS
ANGIOGENESIS
| 最新影响因子：10.658 | 期刊ISSN：0969-6970 | CiteScore：5.08 |
| 出版周期：Quarterly | 是否OA：YES | 出版年份：1997 |
期刊官方网址：https://www.rndsystems.com/cn/research-area/angiogenesis
| 自引率：3.30% | 研究方向：PERIPHERAL VASCULAR DISEASE- |
| 出版地区：NETHERLANDS |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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ANGIOGENESIS 期刊简介
英文简介：
Published by Springer. ISSN (printed): 0969-6970. ISSN (electronic): 1573-7209. Angiogenesis is an international peer-reviewed journal devoted to the publication of top quality original articles
中文简介：（来自Google、百度翻译）
由施普林格出版。ISSN(印刷):0969 - 6970。ISSN(电子):1573 - 7209。 血管生成是一个国际同行评审的杂志，致力于发表高质量的原创文章。
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ANGIOGENESIS 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
PERIPHERAL VASCULAR DISEASE (外周血管病) 2区 |
10/65 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 48 | 37 | 11 |
总被引频次：2956
特征因子：0.004410
影响因子趋势图
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ANGIOGENESIS 期刊CiteScore评价数据
最新CiteScore值
5.08
=
引文计数(2018)
文献(2015-2017)
=
731次引用
144篇文献
文献总数（2014-2016）：144
被引比率：91%
SJR：2.177
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：1.416
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：Physiology
|
#17/169
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| 2 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：Clinical Biochemistry
|
#8/118
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|
|
| 3 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：Cancer Research
|
#33/191
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|
|
CiteScore趋势图
Scopus涵盖范围
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