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Abstract:
:Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and -10 and of macrophage migration inhibitory factor (MIF), exerts beneficial effects on AUD in rodent models and human patients. Therefore, IBUD has attracted increasing interest, with research focusing on the elucidation of the pathogenic role of MIF and its homologue, D-dopachrome tautomerase (DDT), in the pathogenesis and maintenance of AUD. By using DNA microarray analysis, the current study performed a transcriptomic expression analysis of MIF, DDT and their co-receptors, including CD74, C-X-C chemokine receptor (CXCR)2, CXCR4 and CXCR7 in patients with AUD. The results revealed that the transcriptomic levels of MIF, DDT and their receptors were superimposable in the prefrontal cortex of rodents and patients with AUD and human patients. Furthermore, peripheral blood cells from heavy drinkers exhibited a moderate increase in MIF and DDT levels, both at the baseline and following exposure to alcohol-associated cues, based on individual situations that included alcohol-related stimuli resulting in subsequent alcohol use (buying alcohol and being at a bar, watching others drink alcohol). Considering the overlapping effects of MIF and DDT, the inverse Fisher's χ2 test was performed on unadjusted P-values to evaluate the combined effect of MIF and DDT. The results revealed a significant increase in these cytokines in heavy drinkers compared with controls (moderate drinkers). To the best of our knowledge, the present study demonstrated for the first time that MIF and DDT expression was upregulated in the blood of patients with AUD. These results therefore warrant further study to evaluate the role of MIF and DDT in the development and maintenance of AUD, to evaluate their use as biomarkers to predict the psychotherapeutic and pharmacological response of patients with AUD and for use as therapeutic targets.
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最新影响因子:2.751 | 期刊ISSN:1792-0981 | CiteScore:1.5 |
出版周期: | 是否OA:YES | 出版年份:2010 |
自引率:4.10% | 研究方向:MEDICINE, RESEARCH & EXPERIMENTAL- |
出版地区:GREECE |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Experimental and Therapeutic Medicine Experimental and Therapeutic Medicine aims to ensure the rapid publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease. All materials submitted to this journal undergo appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regards to approval of experiments on humans and animals.
实验及治疗医学 实验和治疗医学的目的是确保有关生物学、基因治疗、传染病、微生物学、分子心脏病学和分子外科的研究以印刷和电子形式迅速出版。该杂志欢迎有关分子医学所有方面的研究,以及与疾病机制相关的体外或体内实验模型系统的研究。 所有提交给本杂志的材料都经过该领域专家评审。所有提交的材料都遵循关于批准人类和动物实验的国际准则。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 4区 |
108/133 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
1429 | 1383 | 46 |
引文计数(2018)
文献(2015-2017)
3712次引用
2469篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Immunology and Microbiology
小类(学科):Immunology and Microbiology (miscellaneous)
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#3/4
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Cancer Research
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#148/191
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