发表一篇学和医学成像类SCI论文
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Abstract:
:Lung adenocarcinoma accounts for a high proportion of lung cancers. Though efforts have been made to develop new and effective treatments for this disease, the mortality rate remains high. Gene expression microarrays facilitate the study of lung cancer at the molecular level. The present study aimed to detect differentially expressed protein-coding genes to identify novel biomarkers and therapeutic targets for lung adenocarcinoma. Aberrations in gene expression in lung adenocarcinoma were determined by analysis of mRNA microarray datasets from the Gene Expression Omnibus database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein-protein interaction (PPI) networks and statistical analysis were used to identify the biological functions of the differentially expressed genes (DEGs). The results of the bioinformatics analysis were subsequently validated using reverse transcription-quantitative PCR. A total of 303 DEGs were identified in lung adenocarcinomas, and they were enriched in a number of cancer-associated GO terms and KEGG pathways. DNA topoisomerase 2α (TOP2A), cell division cycle protein homolog 20 (CDC20), mitotic checkpoint serine/threonine protein kinase BUB1 (BUB1) and mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) exhibited the highest degree of interaction in the PPI network. Survival analysis performed using Kaplan-Meier curves and Cox regression indicated that these four genes were all significantly associated with the survival of patients with lung adenocarcinomas. In conclusion, TOP2A, CDC20, BUB1 and MAD2L1 may be key protein-coding genes that may serve as biomarkers and therapeutic targets in lung adenocarcinomas.
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最新影响因子:2.751 | 期刊ISSN:1792-0981 | CiteScore:1.5 |
出版周期: | 是否OA:YES | 出版年份:2010 |
自引率:4.10% | 研究方向:MEDICINE, RESEARCH & EXPERIMENTAL- |
出版地区:GREECE |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Experimental and Therapeutic Medicine Experimental and Therapeutic Medicine aims to ensure the rapid publication, in both print and electronic format, of studies relating to biology, gene therapy, infectious disease, microbiology, molecular cardiology and molecular surgery. The journal welcomes studies pertaining to all aspects of molecular medicine, and relating to in vitro or in vivo experimental model systems relevant to the mechanisms of disease. All materials submitted to this journal undergo appropriate review via referees who are experts in this field. All materials submitted follow international guidelines with regards to approval of experiments on humans and animals.
实验及治疗医学 实验和治疗医学的目的是确保有关生物学、基因治疗、传染病、微生物学、分子心脏病学和分子外科的研究以印刷和电子形式迅速出版。该杂志欢迎有关分子医学所有方面的研究,以及与疾病机制相关的体外或体内实验模型系统的研究。 所有提交给本杂志的材料都经过该领域专家评审。所有提交的材料都遵循关于批准人类和动物实验的国际准则。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 4区 |
108/133 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
1429 | 1383 | 46 |
引文计数(2018)
文献(2015-2017)
3712次引用
2469篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Immunology and Microbiology
小类(学科):Immunology and Microbiology (miscellaneous)
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#3/4
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Cancer Research
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#148/191
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研究方向:基因测序
审稿时间: 12个月内 接受率: 中等(50%命中)
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研究方向:肿瘤
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研究方向:医学 医学:研究与实验
审稿时间: 2个月内
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研究方向:医药科学 皮肤及其附属器 皮肤遗传及相关疾病
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研究方向:生命科学 生物物理、生物化学与分子生物学 生物化学
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研究方向:meta 临床
审稿时间: 3个月内 接受率: 中等(50%命中)
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审稿时间: 3个月内 接受率: 一般容易(75%命中)
影响因子:1.696
ISSN:0174-304X
研究方向:医学-临床神经学
影响因子:4.21
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影响因子:2.363
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研究方向:医学-临床神经学
影响因子:3.042
ISSN:1071-9091
研究方向:CLINICAL NEUROLOGY-PEDIATRICS
影响因子:3.692
ISSN:1090-3798
研究方向:医学-临床神经学
影响因子:4.864
ISSN:0012-1622
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影响因子:9.703
ISSN:0031-4005
研究方向:医学-小儿科
影响因子:5.106
ISSN:1661-7800
研究方向:医学-小儿科
影响因子:2.567
ISSN:1471-2431
研究方向:PEDIATRICS-
发表一篇学和医学成像类SCI论文
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