发表一篇学和医学成像类SCI论文
需要多少钱?
Abstract:
:Myopathies are common manifestations of mitochondrial diseases. To investigate whether gene replacement can be used as an effective strategy to treat or cure mitochondrial myopathies, we have generated a complex I conditional knockout mouse model lacking NDUFS3 subunit in skeletal muscle. NDUFS3 protein levels were undetectable in muscle of 15-day-old smKO mice, and myopathy symptoms could be detected by 2 months of age, worsening over time. rAAV9-Ndufs3 delivered systemically into 15- to 18-day-old mice effectively restored NDUFS3 levels in skeletal muscle, precluding the development of the myopathy. To test the ability of rAAV9-mediated gene replacement to revert muscle function after disease onset, we also treated post-symptomatic, 2-month-old mice. The injected mice showed a remarkable improvement of the mitochondrial myopathy and biochemical parameters, which remained for the duration of the study. Our results showed that muscle pathology could be reversed after restoring complex I, which was absent for more than 2 months. These findings have far-reaching implications for the ability of muscle to tolerate a mitochondrial defect and for the treatment of mitochondrial myopathies.
展开更多
最新影响因子:14.26 | 期刊ISSN:1757-4676 | CiteScore:8.57 |
出版周期:Monthly | 是否OA:YES | 出版年份:2009 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1757-4684
自引率:1.30% | 研究方向:医学-医学:研究与实验 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
EMBO Molecular Medicine publishes research articles as full-length research papers and short reports. In addition, the journal publishes editorials and review articles in innovative formats that target a broad and non-specialized audience. Areas within the scope include, but are not limited to: Aging Angiogenesis Cancer biology Channelopathies Differentiation and development Endocrinology/Metabolic disease Genetics/epigenetics Genomics, transcriptomics, proteomics, metabolomics of disease, systems medicine Gene therapy Immunology and inflammation Infectious diseases Neurodegeneration, neurological diseases and myopathies, sensory defects Stem cells and regenerative medicine Vascular and cardiovascular biology
EMBO分子医学发表研究论文全文和短报告。此外,该杂志还以创新的形式发表社论和评论文章,面向广泛和非专业读者。 范围内的范围包括但不限于: 老化 血管生成 癌症生物学 Channelopathies 分化和发育 内分泌/代谢性疾病 遗传学和表观遗传学 基因组学、转录组学、蛋白质组学、疾病代谢组学、系统医学 基因治疗 免疫学和炎症 传染病 神经退化,神经疾病和肌病,感觉缺陷 干细胞和再生医学 血管与心血管生物学
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 1区 |
7/133 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
109 | 103 | 6 |
引文计数(2018)
文献(2015-2017)
3120次引用
364篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Molecular Medicine
|
#6/161
点击查看排名表
|
|
推荐刊物均可到国家新闻出
版总署网站查询正刊
可签署保密协议 ,不透露任
何用户信息可跟踪进程,全程
协议
1对1服务,7x24小时在线
15年经验沉淀,实体公司
运营
liting7111
研究方向:药物化学 细胞生物学
接受率: 中等(50%命中)
liting7111
liting7111
影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
ISSN:0139-3006
研究方向:农林科学-食品科技
影响因子:3.221
ISSN:1654-6628
研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
ISSN:1662-4025
研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
发表一篇学和医学成像类SCI论文
需要多少钱?
专注医学期刊服务15年
您好:请问您咨询什么等级的期刊?专注医学类期刊发表15年口碑企业,为您提供以下服务:
1.医学核心期刊发表-全流程服务
2.医学SCI期刊-全流程服务
3.论文投稿服务-快速报价
4.期刊推荐直至录用,不成功不收费
客服正在输入...
EMBO Molecular Medicine 投稿经验
(由下方点评分析获得,3人参与,18431人阅读)