
发表一篇学和医学成像类SCI论文
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Abstract:
AIMS:Chemoresistance is a major underlying cause of relapse or death in ovarian cancer patients. Emerging evidence has shown that macrophages could play an essential role in mediating the chemoresistance of cancer cells. MiR-21 has been reported to be an oncogene, which promotes chemoresistance in cancer. Here, we aim to investigate the role that miR-21 plays in polarization of macrophages and ovarian cancer progression. MAIN METHODS:The CIBERSORT algorithm was used to investigate immune cell infiltration in ovarian cancer tissues. To explore the role that miR-21 played in macrophages, M2 macrophages transfected with a miR-21 mimic or a miR-21 inhibitor were co-cultured with ovarian cancer cells. Western blotting was used to detect protein expression levels. CCK8 was used to detect the IC50 of ovarian cancer cells. Flow cytometry was used to detect apoptosis and the cell cycle of ovarian cancer cells. KEY FINDINGS:In this study, we found that higher expression of M1 macrophages and lower expression of M2 macrophages correlated with a better prognosis of ovarian cancer patients. M2 macrophages promoted the chemoresistance of ovarian cancer cells. The results showed that miR-21 could partially regulate the polarization of macrophages. Furthermore, M2 macrophages transfected with the miR-21 mimic significantly promoted chemoresistance and inhibited apoptosis of ovarian cancer cells, while the M2 macrophages transfected with the miR-21 inhibitor showed the opposite effects. SIGNIFICANCE:miR-21 plays an important role in regulating macrophage polarization, therefore increasing the M2 macrophage-mediated chemoresistance in ovarian cancer cells.
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最新影响因子:6.78 | 期刊ISSN:0024-3205 | CiteScore:3.17 |
出版周期:Weekly | 是否OA:YES | 出版年份:1973 |
期刊官方网址:http://www.elsevier.com/wps/find/journaldescription.cws_home/525477/description
期刊投稿地址:http://ees.elsevier.com/lfs/
自引率:2.00% | 研究方向:医学-药学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Life Sciences is an international weekly journal publishing reports on research in biomedical areas. Articles are encouraged that emphasize the molecular, cellular and functional aspects of Cardiovascular & Autonomic Mechanisms; Drug Metabolism; Endocrinology; Growth Factors and Neoplasia; Immunology; Neuroscience and Toxicology. The Journal publishes original research rapidly. Although full-length manuscripts are favored, shorter submissions are also considered. These shorter articles must be of the same high quality as full-length articles, and should contain information from topical and fast-moving fields in order to merit more rapid communication. Mini-reviews on topics of wide interest to investigators in the life sciences are also published. All articles are rigorously reviewed. The Journal favors publication of papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research.
《生命科学》是一份国际周刊,出版生物医学领域的研究报告。鼓励强调心血管和自主机制的分子、细胞和功能方面的文章;药物代谢;内分泌学;生长因子与肿瘤;免疫学;神经学和毒理学。该杂志迅速发表原创研究。虽然全篇幅的稿件更受欢迎,但也可以考虑提交较短的稿件。这些较短的文章必须与完整的文章具有相同的高质量,并且应该包含来自主题和快速移动领域的信息,以便进行更快速的交流。对生命科学研究人员广泛感兴趣的主题也发表了小型评论。所有文章都经过严格审查。该杂志倾向于发表现代科学技术用于解释分子、细胞和生理机制的论文。仅仅报告观察结果的文章很少被接受。必须遵守《赫尔辛基宣言》或国家卫生研究院关于护理和使用实验室动物的指导方针的建议。文章应该写在对文章主题本身不是专家,但对研究感兴趣的读者能够理解的水平上。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 3区 PHARMACOLOGY & PHARMACY (药学) 3区 |
53/133 78/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
337 | 287 | 50 |
引文计数(2018)
文献(2015-2017)
4020次引用
1267篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):General Biochemistry, Genetics and Molecular Biology
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#41/187
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2 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):General Pharmacology, Toxicology and Pharmaceutics
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#4/68
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研究方向:生命科学 生物物理、生物化学与分子生物学 生物化学
审稿时间: 1个月内
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研究方向:肝脏 缺血再灌注 氢气
审稿时间: 2个月内
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研究方向:炎症 内皮功能 血管
审稿时间: 3个月内 接受率: 中等(50%命中)
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接受率: 中等(50%命中)
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研究方向:神经 衰老 阿尔兹海默症
审稿时间: 3个月内 接受率: 一般容易(75%命中)
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研究方向:生命科学 微生物学 微生物生理与生物化学
审稿时间: 4个月内
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影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
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研究方向:农林科学-食品科技
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研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
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研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
影响因子:0.704
ISSN:0985-0562
研究方向:医学-内分泌学与代谢
LIFE SCIENCES 投稿经验
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