
发表一篇学和医学成像类SCI论文
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Abstract:
:Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC) surgeries, as intraoperative techniques for real-time evaluation of the resection margins are lacking. In this study, we investigated the safety and potential clinical value of fluorescence-guided imaging (FGI) for resection margin evaluation in HNC patients. We determined the optimal cetuximab-800CW dose by quantification of intrinsic fluorescence values using multi-diameter single-fiber reflectance, single-fiber fluorescence (MDSFR/SFF) spectroscopy. Methods: Five cohorts of three HNC patients received cetuximab-800CW systemically: three single dose cohorts (10, 25, 50 mg) and two cohorts pre-dosed with 75 mg unlabeled cetuximab (15 or 25 mg). Fluorescence visualization and MDSFR/SFF spectroscopy quantification was performed and were correlated to histopathology. Results: There were no study-related adverse events higher than Common Terminology Criteria for Adverse Events grade-II. Quantification of intrinsic fluorescence values showed a dose-dependent increase in background fluorescence in the single dose cohorts (p<0.001, p<0.001), which remained consistently low in the pre-dosed cohorts (p=0.6808). Resection margin status was evaluated with a sensitivity of 100% (4/4 tumor-positive margins) and specificity of 91% (10/11 tumor-negative margins). Conclusion: A pre-dose of 75 mg unlabeled cetuximab followed by 15 mg cetuximab-800CW was considered the optimal dose based on safety, fluorescence visualization and quantification of intrinsic fluorescence values. We were able to use a lower dose cetuximab-800CW than previously described, while remaining a high sensitivity for tumor detection due to application of equipment optimized for IRDye800CW detection, which was validated by quantification of intrinsic fluorescence values.
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最新影响因子:11.6 | 期刊ISSN:1838-7640 | CiteScore:8.7 |
出版周期: | 是否OA:YES | 出版年份:2011 |
期刊官方网址:http://www.thno.org/
自引率:7.70% | 研究方向:MEDICINE, RESEARCH & EXPERIMENTAL- |
出版地区:AUSTRALIA |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The aim of Theranostics is to provide a forum for the exchange of clinical and scientific information for the diagnostic and therapeutic molecular and nano medicine community and allied professions involved in the efforts of integrating molecular imaging and molecular therapy. Theranostics is a multidisciplinary journal that publishes innovative and original research articles reflecting fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor, nanobiosensor and bioelectronics, system biology and translational medicine, point-of-care and personalized medicine. A broad spectrum of biomedical research that can be applied to future theranostic applications is encouraged. In addition to primary research, Theranostics also publishes reviews, news, and commentary to understand and bridge the gap among the laboratory, clinic, and biotechnology industries. Papers in the journal are rigorously peer-reviewed.
Theranostics的目的是为诊断和治疗分子和纳米医学社区以及相关专业提供一个交流临床和科学信息的论坛,这些专业致力于将分子成像和分子治疗结合起来。Theranostics是一份多学科期刊,发表创新和原创的研究文章,反映了体外诊断和预测、体内分子成像、分子治疗、图像引导治疗、生物传感器、纳米生物传感器和生物电子学、系统生物学和转化医学、定点医疗和个性化医疗等领域。鼓励广泛的生物医学研究,可应用于未来的theranostic应用。除了初级研究,Theranostics还出版评论、新闻和评论,以了解和弥合实验室、临床和生物技术行业之间的差距。杂志上的论文都经过严格的同行评审。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 2区 |
8/133 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
353 | 323 | 30 |
引文计数(2018)
文献(2015-2017)
3480次引用
400篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Medicine (miscellaneous)
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#4/189
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2 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
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#1/22
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研究方向:治疗靶点 分子生物 生物治疗
接受率: 比较困难(25%命中)
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研究方向:药物性肝损伤 自噬
接受率: 比较困难(25%命中)
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研究方向:医药科学 肿瘤学 肿瘤发生
审稿时间: 5个月内
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研究方向:炎症 表观遗传
影响因子:5.576
ISSN:0885-3924
研究方向:医学-临床神经学
影响因子:6.005
ISSN:0192-415X
研究方向:医学-全科医学与补充医学
影响因子:202.731
ISSN:0140-6736
研究方向:医学-医学:内科
影响因子:2.898
ISSN:1807-5932
研究方向:医学-医学:内科
影响因子:1.817
ISSN:0025-7974
研究方向:医学-医学:内科
影响因子:3.006
ISSN:2044-6055
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
ISSN:0020-9554
研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
Theranostics 投稿经验
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