发表一篇学和医学成像类SCI论文
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Abstract:
:Gastric cancer (GC) is a commonly diagnosed malignancy with a high mortality rate worldwide. Despite advances in therapeutic approaches, the 5-year survival rate of patients with GC remains poor. A type of non-coding RNA, circular RNA (circRNA), has been discovered. Some circRNAs are dysregulated in cancer and may have important functions. Thus, circRNAs could be candidate biomarkers for disease diagnosis and prognosis. Our study used a reannotation framework to derive expression values of circRNAs from microarray data sets. We used an integrated pipeline including differential expression analysis and Cox regression analyses to detect GC-associated circRNA signatures. We validated results with 54 paired gastric tumor and adjacent normal tissues. Five circRNA signatures were highly associated with patient overall survival and disease-free survival. Real-time PCR experiments on hsa_circ_0103398 and hsa_circ_0127859 in tumors and normal tissues showed that these circRNAs were significantly upregulated in GC. High expression of hsa_circ_0103398 and hsa_circ_0127859 was closely associated with unfavorable survival time. Our findings indicated that a 5-circRNA signature might serve as a candidate prognostic biomarker of GC.
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最新影响因子:3.235 | 期刊ISSN:1081-5589 | CiteScore:1.82 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1994 |
自引率:1.10% | 研究方向:医学-医学:内科 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by BC Decker. ISSN: 1081-5589. The Journal of Investigative Medicine offers original investigations and articles detailing the latest developments in interdisciplinary disease-oriented medical research. The Journal also provides: information about policy changes affecting academic medicine, physician investigators, and the clinical biomedical research community; interviews with prominent members of the medical research community; news on federal regulatory changes; and professional recruitment and research funding guides. Discontinued in 2004.
由BC Decker出版。ISSN: 1081-5589。 调查医学杂志提供了原始的调查和文章,详细介绍了跨学科疾病为导向的医学研究的最新发展。该杂志还提供:有关政策变化影响学术医学,医生调查人员和临床生物医学研究社区的信息;采访医学研究领域的杰出人士;有关联邦监管改革的新闻;以及专业的招聘和研究资助指南。在2004年停止。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICINE, GENERAL & INTERNAL (医学:内科) 3区 MEDICINE, RESEARCH & EXPERIMENTAL (医学:研究与实验) 4区 |
55/155 85/133 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
60 | 51 | 9 |
引文计数(2018)
文献(2015-2017)
374次引用
206篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):General Biochemistry, Genetics and Molecular Biology
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#70/187
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研究方向:医药科学 循环系统 血压调节异常与高血压病
审稿时间: 2个月内
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审稿时间: 24个月内 接受率: 非常困难(几乎不命中)s
影响因子:2.67
ISSN:1054-6006
研究方向:农林科学-海洋学
影响因子:3.906
ISSN:1054-3139
研究方向:农林科学-海洋学
影响因子:3.994
ISSN:0304-4203
研究方向:化学-海洋学
影响因子:5.763
ISSN:0022-2828
研究方向:医学-细胞生物学
影响因子:3.128
ISSN:2228-5806
研究方向:CELL BIOLOGY-
影响因子:5.063
ISSN:2044-5040
研究方向:CELL BIOLOGY-
影响因子:0.308
ISSN:0884-6812
研究方向:CELL BIOLOGY-
影响因子:2.5
ISSN:0025-3235
研究方向:地学-地球化学与地球物理
影响因子:2.049
ISSN:0377-0265
研究方向:地学-地球化学与地球物理
发表一篇学和医学成像类SCI论文
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