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Abstract:
BACKGROUND:Point-of-care (POC) measurement of glucose is currently recommended only for the monitoring of gestational diabetes mellitus (GDM). This prospective observational study evaluated the use of POC measurements of maternal glucose to diagnose GDM in women being screened selectively with a 1-step 75 g oral glucose tolerance test (OGTT). METHODS:The strictest preanalytic and analytic international laboratory standards were applied to measure maternal plasma glucose at fasting and at 1 and 2 h post glucose load. The recent International Association of Diabetes and Pregnancy Study Groups diagnostic criteria were used. At the same time, maternal capillary glucose was measured. Because of differences in plasma and capillary glucose measurements, regression analysis of POC capillary glucose results vs laboratory plasma glucose results was conducted. The regression equations for plasma glucose were derived in a derivation cohort (n = 102). These equations were applied in the validation cohort (n = 100). Predicted and actual plasma glucose values were compared. RESULTS:Of the 202 women screened, 36.6% were nulliparous, 56.4% were obese, and 81.2% were Irish-born. Two thirds had a single risk factor for GDM, and a third had multiple risk factors. Based on the plasma measurements, 53.5% had GDM. As a predictor of GDM, the diagnostic accuracy of POC measurement was 83.0% (95% confidence interval, 74.2-89.8). CONCLUSIONS:In high-resource settings where measures to inhibit glycolysis are implemented, the use of POC measurements for the diagnosis of GDM is not justified based on this study. In low- and medium-resource settings, where measures to inhibit glycolysis are not achievable, regression analysis using POC measurements may be acceptable compared with plasma samples subject to glycolysis.
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最新影响因子:12.167 | 期刊ISSN:0009-9147 | CiteScore:3.21 |
出版周期:Monthly | 是否OA:YES | 出版年份:1955 |
期刊官方网址:http://www.clinchem.org/
自引率:5.80% | 研究方向:医学-医学实验技术 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today s clinical laboratory. In addition to being the most cited journal in the field (over 18,000 citations in 2005), Clin Chem has the highest Impact Factor (7.717 in 2005) among journals of clinical chemistry, clinical (or anatomic) pathology, analytical chemistry, and the subspecialties, such as transfusion medicine, clinical microbiology. The journal issued monthly, publishes contributions, either experimental or theoretical, that concern basic materials or principles, analytical and molecular diagnostic techniques, instrumentation, data processing, statistical analyses of data, clinical investigations in which chemistry has played a major role, or laboratory animal studies of chemically oriented problems of human disease.
临床化学是当今临床实验室进行同行评审、原创研究的领先论坛。在临床化学、临床(或解剖)病理学、分析化学、输血医学、临床微生物学等分支学科期刊中,Clin Chem除了是该领域被引用最多的期刊(2005年被引用超过18000次)外,其影响因子最高(2005年为7.717)。该杂志每月出版一期,发表有关基本材料或原理、分析和分子诊断技术、仪器仪表、数据处理、数据统计分析、化学在其中发挥重要作用的临床研究或针对人类疾病的化学问题的实验室动物研究的实验或理论贡献。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
MEDICAL LABORATORY TECHNOLOGY (医学实验技术) 1区 |
1/30 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
153 | 123 | 30 |
引文计数(2018)
文献(2015-2017)
3022次引用
941篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Clinical Biochemistry
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#26/118
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2 |
大类(学科):Medicine
小类(学科):Biochemistry (medical)
|
#10/50
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研究方向:化学科学 分析化学 质谱分析
审稿时间: 1个月内
影响因子:5.576
ISSN:0885-3924
研究方向:医学-临床神经学
影响因子:6.005
ISSN:0192-415X
研究方向:医学-全科医学与补充医学
影响因子:202.731
ISSN:0140-6736
研究方向:医学-医学:内科
影响因子:2.898
ISSN:1807-5932
研究方向:医学-医学:内科
影响因子:1.817
ISSN:0025-7974
研究方向:医学-医学:内科
影响因子:3.006
ISSN:2044-6055
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
ISSN:0020-9554
研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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