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CONTEXT:Normocalcemic hyperparathyroidism (NPHPT) is characterized by persistently normal calcium levels and elevated parathyroid hormone (PTH) values, after excluding other causes of secondary hyperparathyroidism. The prevalence of the disease varies greatly and the data on the natural history of this disease are sparse and inconclusive. OBJECTIVES:The objectives of this study are to describe the prevalence of NPHPT and its natural history in a referral population and to compare the variability of serum calcium with a group of patients with primary hyperparathyroidism (PHPT). DESIGN:A retrospective study was conducted over 5 years. SETTING:The setting for this study was a metabolic bone referral center. PATIENTS:A total of 6280 patients were referred for a bone mineral density measurement (BMD). MAIN OUTCOME MEASURES:The prevalence and natural history of NPHPT and variability of calcium were the main outcome measures. RESULTS:We identified NPHPT patients using data from the day of the BMD measurement. We excluded patients with low estimated glomerular filtration rate (eGFR) or vitamin D, or with no measurements available. Based on the evaluation of their medical files, we identified 11 patients with NPHPT (prevalence 0.18%). Only 4 patients had consistent normocalcemia throughout their follow-up, with only 2 also having consistently high PTH. None had consistently normal eGFR or vitamin D.Intermittent hypercalcemia was present in 7 of the 11 NPHPT patients. The mean adjusted calcium was found to be significantly lower in the NPHPT group compared with the PHPT group but higher than the control group. PTH was similar for NPHPT and PHPT. These 2 groups had similar variability in serum calcium. CONCLUSIONS:NPHPT patients often have episodes of hypercalcemia. We believe that NPHPT is a mild form of PHPT.
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最新影响因子:6.134 | 期刊ISSN:0021-972X | CiteScore:0.0 |
出版周期:Monthly | 是否OA:YES | 出版年份:1952 |
自引率:4.00% | 研究方向:医学-内分泌学与代谢 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Clinical Endocrinology & Metabolism is the world''s leading peer reviewed journal of clinical practice and applied clinical research. Each issue provides fast and in depth coverage of diabetes, reproductive endocrinology, growth hormone therapy, thyroid disease, and other critical areas of clinical endocrinology. Regular features highlight current topics in clinical medicine, such as clinical studies, clinical case seminars, management of endocrine disorders, practice management issues, original patent oriented research studies, and other significant new endocrine studies related to human physiology and disease. According to the latest ISI Journal Citation Report, JCE&M articles were cited almost 38,000 times in 2000. It has the highest Impact Factor ranking (#9) of any clinical journal in the ISI category of endocrinology and metabolism.
《临床内分泌与代谢杂志》是世界领先的临床实践和应用临床研究的同行评审期刊。每个问题提供快速和深入的报道糖尿病,生殖内分泌学,生长激素治疗,甲状腺疾病和其他关键领域的临床内分泌。定期专题突出当前临床医学的主题,如临床研究、临床病例研讨会、内分泌疾病管理、实践管理问题、原始专利导向的研究,以及其他与人类生理和疾病相关的重要内分泌新研究。根据ISI期刊最新的引文报告,2000年,JCE&M的文章被引用了近3.8万次。在内分泌和代谢的ISI分类中,它是所有临床杂志中影响因子排名最高的(第9)。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 2区 |
20/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
491 | 476 | 15 |
引文计数(2018)
文献(2015-2017)
0次引用
99篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#208/209
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研究方向:代谢
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研究方向:代谢
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研究方向:甲状腺癌 临床 治疗
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:代谢
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研究方向:糖尿病手术
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研究方向:代谢
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研究方向:内分泌
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审稿时间: 1个月内
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研究方向:diabetes thrombosis
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研究方向:糖尿病
接受率: 比较困难(25%命中)
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研究方向:甲状旁腺功能减退症 基因多态性 治疗
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研究方向:代谢
接受率: 比较困难(25%命中)
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影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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