发表一篇学和医学成像类SCI论文
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Abstract:
:Fetal growth restriction (FGR) and prematurity are often co-morbidities, and both are risk factors for lung disease. Despite advances in early delivery combined with supportive ventilation, rates of ventilation-induced lung injury (VILI) remain high. There are currently no protective treatments or interventions available that target lung morbidities associated with FGR preterm infants. Stem cell therapy, such as umbilical cord blood (UCB) cell administration, demonstrates an ability to attenuate inflammation and injury associated with VILI in preterm appropriately grown animals. However, no studies have looked at the effects of stem cell therapy in growth restricted newborns. We aimed to determine if UCB treatment could attenuate acute inflammation in the first 24 h of ventilation, comparing effects in lambs born preterm following FGR with those born preterm but appropriately grown (AG). Placental insufficiency (FGR) was induced by single umbilical artery ligation in twin-bearing ewes at 88 days gestation, with twins used as control (appropriately grown, AG). Lambs were delivered preterm at ~126 days gestation (term is 150 days) and randomized to either immediate euthanasia (unventilated controls, AGUVC and FGRUVC) or commenced on 24 h of gentle supportive ventilation (AGV and FGRV) with additional cohorts receiving UCB treatment at 1 h (AGCELLS, FGRCELLS). Lungs were collected at post-mortem for histological and biochemical examination. Ventilation caused lung injury in AG lambs, as indicated by decreased septal crests and elastin density, as well as increased inflammation. Lung injury in AG lambs was attenuated with UCB therapy. Ventilated FGR lambs also sustained lung injury, albeit with different indices compared to AG lambs; in FGR, ventilation reduced septal crest density, reduced alpha smooth muscle actin density and reduced cell proliferation. UCB treatment in ventilated FGR lambs further decreased septal crest density and increased collagen deposition, however, it increased angiogenesis as evidenced by increased vascular endothelial growth factor (VEGF) expression and vessel density. This is the first time that a cell therapy has been investigated in the lungs of growth restricted animals. We show that the uterine environment can alter the response to both secondary stress (ventilation) and therapy (UCB). This study highlights the need for further research on the potential impact of novel therapies on a growth restricted offspring.
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自引率:4.30% | 研究方向:- |
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SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The specialty sections of Frontiers in Endocrinology welcome submission of the followingarticle types: Book Review, Case Report, Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Protocols, Review, Specialty Grand Challenge, Technology Report, Clinical Study Protocol, Addendum and Erratum. When submitting a manuscript to Frontiers in Endocrinology, authors must submit the material directly to one of the specialty sections. Manuscripts are peer-reviewed by the Associate and Review Editors of the respective specialty section. Articles published in the specialty sections above will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in the Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all ofEndocrinology.
内分泌学前沿专业欢迎提交以下文章类型:书评、病例报告、临床试验、纠正、数据报告、编辑、一般评论、假设与理论、方法、小综述、意见、原始研究、观点、协议、综述、专业大挑战、技术报告、临床研究协议、增编和勘误表。 在向内分泌学前沿投稿时,作者必须将稿件直接提交给某个专业部门。稿件由相关专业部门的助理编辑和审稿编辑进行同行评审。 在上述专业板块发表的文章将受益于在线出版后的前沿影响和分级系统。具有最高影响力的已发表原创研究的作者,通过读者的民主判断,将由主编邀请撰写一篇聚焦前沿的评论——一篇逐级攀升的文章。这就是所谓的“民主分层”。作者的选择是基于发表在前沿专业期刊和部分的原创研究的文章影响分析。重点审查集中在最初的发现,把它放在一个更广泛的背景下,并旨在解决更广泛的社区所有内分泌学。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 3区 |
52/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
330 | 192 | 138 |
引文计数(2018)
文献(2015-2017)
2154次引用
539篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#29/209
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研究方向:endocrinology
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影响因子:3.752
ISSN:1293-2558
研究方向:化学-无机化学与核化学
影响因子:2.961
ISSN:0947-7047
研究方向:化学-电化学
影响因子:2.07
ISSN:0039-6028
研究方向:化学-物理:凝聚态物理
影响因子:13.417
ISSN:0167-5729
研究方向:化学-物理:凝聚态物理
影响因子:1.838
ISSN:0031-9104
研究方向:化学-物理:凝聚态物理
影响因子:15.153
ISSN:1613-6810
研究方向:工程技术-材料科学:综合
影响因子:12.262
ISSN:1530-6984
研究方向:工程技术-材料科学:综合
影响因子:32.086
ISSN:0935-9648
研究方向:工程技术-材料科学:综合
影响因子:19.924
ISSN:1616-301X
研究方向:工程技术-材料科学:综合
发表一篇学和医学成像类SCI论文
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