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Abstract:
:Hypocalcemia was reported at low rates (0.05-1.7%) in denosumab-treated postmenopausal women with osteoporosis. This real-life study shows a 7.4% rate of denosumab-induced hypocalcemia in community-dwelling osteoporotic men and women. Pretreatment serum calcium and creatinine levels are major predictors for this complication. Serum-calcium monitoring may help to identify and prevent severe hypocalcemia. PURPOSE:RCTs have reported a 0.05-1.7% rate of hypocalcemia in denosumab-treated postmenopausal women with osteoporosis, but long-term real-life data are lacking. We assessed the rate of hypocalcemia in osteoporotic community-dwelling patients treated with denosumab. METHODS:A retrospective analysis was conducted based on medical records (2010-2018) from a large HMO. An albumin-adjusted serum calcium concentration lower than 8.5 mg/dL was defined as hypocalcemia. RESULTS:We included 2005 patients (93% women, mean age 76 ± 9 years). Hypocalcemia developed during treatment in 149 patients (7.4%; 1% less than 8 mg/dL): in 66 after 0.5-1 years; 48 after 1-2 years; 35 after > 2 years. On comparison of the hypocalcemic and normocalcemic patients, the strongest predictors of hypocalcemia were pretreatment levels of albumin-adjusted serum calcium (9.1 ± 0.4 vs. 9.4 ± 0.5 mg/dL, respectively; p < 0.05) and creatinine (0.9 ± 0.5 vs. 0.8 ± 0.3 mg/dL, respectively; p < 0.05). The hypocalcemia rate increased in parallel to a decrease in eGFR (p = 0.032 for the difference between eGFR ranges). Baseline calcium level ≤ 9.31 mg/dL predicted hypocalcemia with a sensitivity of 77% and specificity of 56%. A model of (- 2)*calcium + creatinine predicted hypocalcemia (3.7% when lower and 17.1% when higher than - 17.4). Gender, age, 25-hydroxyvitamin-D, parathyroid hormone, alkaline phosphatase, and whether denosumab was given as first or advanced line of osteoporotic therapy had no predictive value. CONCLUSION:Real-life rates of denosumab-induced hypocalcemia are higher than previously reported. Hypocalcemia might develop after each dose of denosumab in ongoing treatment. Adequate calcium and vitamin D supplementation are needed. Serum calcium monitoring is advised in high-risk patients for early detection of severe hypocalcemia.
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最新影响因子:5.071 | 期刊ISSN:0937-941X | CiteScore:3.5 |
出版周期:Monthly | 是否OA:YES | 出版年份:1990 |
期刊官方网址:http://www.springer.com/medicine/orthopedics/journal/198
期刊投稿地址:http://mc.manuscriptcentral.com/oi?PROXY_TO_PAGE_NAME=&PRE_ACTION=&DISPLAY=&CURRENT_PAGE=LOGIN&SAVE_
自引率:12.00% | 研究方向:医学-内分泌学与代谢 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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An international multi-disciplinary journal which is a joint ititiative between the International Osteoporosis and the National Osteoporosis Foundation of the USA the journal provides the journal a forum for the communication and exchange of current ideas concerning osteoporosis. It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition; correspondence - concerning matters of topical interest or relating to publisher's material; book reviews; reports of meetings; Society announcements; etc.
《骨质疏松》是国际骨质疏松症基金会与美国国家骨质疏松症基金会联合创办的国际性多学科期刊,为当前有关骨质疏松症的学术交流提供了一个平台。它出版:原始论文-报告骨质疏松症及其相关领域的所有领域的进展和结果;审查文章-反映在总结已导致明确界定结论的有限主题的特定领域的知识现状;教育性文章-就特别感兴趣的课题的进展情况提供资料;病例报告-罕见或有趣的症状表现;与时事有关或与出版商资料有关的信件;书评;会议报告;社会公告;等。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 3区 |
40/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
348 | 306 | 42 |
引文计数(2018)
文献(2015-2017)
3859次引用
1101篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#40/209
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研究方向:骨质疏松
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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接受率: 中等(50%命中)
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研究方向:脊柱外科内固定研发 骨质疏松 骨代谢
接受率: 比较困难(25%命中)
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研究方向:医药科学 运动系统 骨、关节、软组织退行性病变
审稿时间: 2个月内
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研究方向:骨代谢临床文章
审稿时间: 3个月内
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研究方向:医药科学 内分泌系统 骨代谢异常 骨质疏松
审稿时间: 1个月内
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研究方向:骨科 内分泌
审稿时间: 2个月内
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研究方向:医药科学
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研究方向:orthopeaqdics
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
影响因子:2.493
ISSN:0925-4927
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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