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Abstract:
Purpose The role of thyroid autoimmunity in the association between obesity and hyperthyrotropinaemia remains unclear. We aimed to assess the relationship between obesity, autoimmunity, and hyperthyrotropinaemia. Methods In this population-based cross-sectional study, 12531 Chinese individuals (18–80 years) with thyroid function test were categorized into three groups by body mass index (BMI) and were categorized into three layers by thyroid autoantibodies. Multivariate logistic regression was employed to assess the correlation and interaction effect. Results There was no significant difference in prevalence of hyperthyrotropinaemia ( P = 0.637) among three BMI groups. After stratification, the difference of serum thyrotropin ( P < 0.01) and prevalence of hyperthyrotropinaemia ( P < 0.01) between the three groups have significant linear trends at the positive levels of thyroid peroxidase antibody (TPOAb) or/and thyroglobulin antibody (TgAb). When TPOAb and TgAb were positive, the risk of hyperthyrotropinaemia increased 1.857-fold in overweight group and 2.201-fold in obese group compared with normal group. Compared with negative TPOAb and TgAb, the risk of hyperthyrotropinaemia for individuals with two positive antibodies increased 3.310-fold, 4.969-fold, and 5.122-fold in the three BMI groups. The adjusted OR (95% CI) for interaction were 1.033 (0.752–1.419) for overweight and one positive antibodies, 1.935 (1.252–2.990) for overweight and two positive antibodies, 1.435 (0.978–2.105) for obesity and one positive antibodies and 2.191 (1.252–3.832) for obesity and two positive antibodies. Conclusion Overweight and obesity were associated with hyperthyrotropinaemia only in presence of thyroid autoimmunity, and obesity might aggravate the pathogenic effect of autoimmunity on hyperthyrotropinaemia. There was an interaction effect between obesity and autoimmunity on the prevalence of hyperthyrotropinaemia.
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最新影响因子:3.925 | 期刊ISSN:1355-008X | CiteScore:2.55 |
出版周期: | 是否OA:YES | 出版年份:1994 |
自引率:9.60% | 研究方向:ENDOCRINOLOGY & METABOLISM- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Well-established as a major journal in today's rapidly advancing experimental and clinical research, Endocrine should be your first choice for the rapid publication of full length articles devoted to the molecular, cellular, biochemical, and physiological aspects of endocrinology, including both clinical papers relating to significant endocrine phenomena that are appropriately controlled and methodological papers of special interest to workers in this area.
完善作为主要在当今迅速发展的实验和临床研究杂志,内分泌的快速出版应该是你首选完整文章致力于分子,细胞,生化,内分泌学和生理方面的,包括临床论文重要内分泌相关现象,适当控制和方法论的论文工作者在这一领域的特殊利益。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 3区 |
62/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
303 | 272 | 31 |
引文计数(2018)
文献(2015-2017)
2668次引用
1047篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
|
#77/209
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|
2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Endocrinology
|
#54/119
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审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:生物化学与分子生物学
接受率: 一般容易(75%命中)
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研究方向:垂体 甲状腺
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:医药科学 内分泌系统
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研究方向:甲状腺超声诊断 甲状腺消融 腹部、肝移植超声
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研究方向:内分泌 代谢
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影响因子:1.754
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发表一篇学和医学成像类SCI论文
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