发表一篇学和医学成像类SCI论文
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Abstract:
Background/aims We assessed the levels of autophagy and mitophagy, that are linked to cancer development and drug resistance, in well differentiated pancreatic neuroendocrine neoplasms (PanNENs) and correlated them with clinico-pathological parameters. Methods Fluorescent immunostaining for the autophagy markers LC3Β and p62/or LAMP1 was performed on 22 PanNENs and 11 controls of normal pancreatic tissues and validated through Western blotting. Autophagy quantitative scoring was generated for LC3B-positive puncta and analysed in relation to clinico-pathological parameters. TOMM20/LC3B qualitative assessment of mitophagy levels was undertaken by fluorescent immunostaining. The presence of autophagy/mitophagy was validated by transmission electron microscopy. Results Autophagy levels (LC3B-positive puncta/cell) were discriminative for normal vs. NEN pancreatic tissue ( p = 0.007). A significant association was observed between autophagy levels and tumour grade (Ki67 < 3% vs. Ki67 ≥ 3%; p = 0.021), but not functionality ( p = 0.266) size (cut-off of 20 mm; p = 0.808), local invasion ( p = 0.481), lymph node- ( p = 0.849) and distant metastases ( p = 0.699). Qualitative assessment of TOMM20/LC3B demonstrated strong mitophagy levels in PanNENs by fluorescent immunostaining as compared with normal tissue. Transmission electron microscopy revealed enhanced autophagy and mitophagy in PanNEN tissue. Response to molecular targeted therapies in metastatic cases ( n = 4) did not reveal any patterns of association to autophagy levels. Conclusions Increased autophagy levels are present in primary tumours of patients with PanNENs and are partially attributed to upregulated mitophagy. Grade was the only clinico-pathological parameter associated with autophagy scores.
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最新影响因子:3.925 | 期刊ISSN:1355-008X | CiteScore:2.55 |
出版周期: | 是否OA:YES | 出版年份:1994 |
自引率:9.60% | 研究方向:ENDOCRINOLOGY & METABOLISM- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Well-established as a major journal in today's rapidly advancing experimental and clinical research, Endocrine should be your first choice for the rapid publication of full length articles devoted to the molecular, cellular, biochemical, and physiological aspects of endocrinology, including both clinical papers relating to significant endocrine phenomena that are appropriately controlled and methodological papers of special interest to workers in this area.
完善作为主要在当今迅速发展的实验和临床研究杂志,内分泌的快速出版应该是你首选完整文章致力于分子,细胞,生化,内分泌学和生理方面的,包括临床论文重要内分泌相关现象,适当控制和方法论的论文工作者在这一领域的特殊利益。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM (内分泌学与代谢) 3区 |
62/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
303 | 272 | 31 |
引文计数(2018)
文献(2015-2017)
2668次引用
1047篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
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#77/209
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Endocrinology
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#54/119
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审稿时间: 2个月内 接受率: 中等(50%命中)
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接受率: 一般容易(75%命中)
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审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:生物化学与分子生物学
接受率: 一般容易(75%命中)
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研究方向:垂体 甲状腺
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:医药科学 内分泌系统
审稿时间: 1个月内
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研究方向:甲状腺超声诊断 甲状腺消融 腹部、肝移植超声
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接受率: 一般容易(75%命中)
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研究方向:内分泌 代谢
审稿时间: 2个月内
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审稿时间: 2个月内 接受率: 一般容易(75%命中)
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研究方向:内分泌 糖尿病
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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