The thyroid hormone inactivator enzyme, Type 3 deiodinase, is essential for coordination of keratinocyte growth and differentiation.

Abstract:
:Thyroid hormones (THs) are key regulators of development, tissue differentiation and maintenance of metabolic balance in virtually every cell of the body. Accordingly, severe alteration of TH action during fetal life leads to permanent deficits in humans. The skin is among the few adult tissues expressing the oncofetal protein type 3 deiodinase (D3), the TH inactivating enzyme. Here, we demonstrate that D3 is dynamically regulated during epidermal ontogenesis. To investigate the function of D3 in a post-developmental context, we used a mouse model of conditional epidermal-specific D3 depletion. Loss of D3 resulted in tissue hypoplasia and enhanced epidermal differentiation in a cell-autonomous manner. Accordingly, wound healing repair and hair follicle cycle were altered in the D3-depleted epidermis. Furthermore, in vitro ablation of D3 in primary culture of keratinocytes indicated that various markers of stratified epithelial layers were up-regulated, thereby confirming the pro-differentiative action of D3 depletion and the consequent increased intracellular T3 levels. Notably, loss of D3 reduced the clearance of systemic TH in vivo, thereby demonstrating the critical requirement for epidermal D3 in the maintenance of TH homeostasis. In conclusion, our results show that the D3 enzyme is a key TH-signaling component in the skin thereby providing a striking example of a physiological context for deiodinase-mediated TH metabolism, as well as a rationale for therapeutic manipulation of deiodinases in patho-physiological contexts.
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THYROID
THYROID
最新影响因子:6.506 | 期刊ISSN:1050-7256 | CiteScore:5.64 |
出版周期:Monthly | 是否OA:YES | 出版年份:1990 |
自引率:10.70% | 研究方向:医学-内分泌学与代谢 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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THYROID 期刊简介
英文简介:
This peer-reviewed journal publishes original articles and reviews reflecting the ever-expanding activities in the thyroid field, from the molecular biology of the cell to clinical management of thyroid disorders. The official journal of the American Thyroid Association.
中文简介:(来自Google、百度翻译)
这本同行评议的杂志发表了反映甲状腺领域不断扩大的活动的原始文章和评论,从细胞的分子生物学到甲状腺疾病的临床管理。美国甲状腺协会官方期刊。
THYROID 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ENDOCRINOLOGY & METABOLISM(内分泌学和新陈代谢) 2区 |
9/142 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
178 | 170 | 8 |
影响因子趋势图
THYROID 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
3624次引用
643篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Endocrinology, Diabetes and Metabolism
|
#11/209
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Endocrinology
|
#7/119
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|
|
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liting7111
12年投中一篇,很有难度。2020-06-02 -
liting7111
审稿时间: 6个月内 接受率: 比较困难(25%命中)
投稿难度较大!2020-05-24 -
liting7111
杂志比较严格,修回两次还是被拒稿了。投稿到一审大约1个月。2020-05-03 -
liting7111
自噬研究从15年开始就不行了,中标率已接近零!2020-03-09 -
liting7111
这杂志在甲状腺方面还是很权威的。2020-01-28 -
liting7111
杂志要收审稿费85刀!,"There is a non-refundable $85 per manuscript submission fee to subsidize the cost of manuscript processing. This non-refundable fee is charged regardless of the editorial outcome and/or decision."2020-01-24 -
liting7111
今年影响因子7.557,直线上升,难度又增加了,希望这次的投稿能中!2020-01-03 -
liting7111
研究方向:临床 影像 肿瘤
刚接收一篇,老天保佑,杂志接受率估计35%左右。2019-10-13 -
liting7111
25天一审回来,两个审稿人给了42条意见,要求大修,限期三个月,意见比较中肯,比较抓细节,图标修改时间占了三分之二。2019-05-25
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