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发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND:N-nitroso compounds are hypothesized human bladder carcinogens. We investigated ingestion of N-nitroso compound precursors nitrate and nitrite from drinking water and diet and bladder cancer in the New England Bladder Cancer Study. METHODS:Using historical nitrate measurements for public water supplies and measured and modeled values for private wells, as well as self-reported water intake, we estimated average nitrate concentrations (mg/L NO3-N) and average daily nitrate intake (mg/d) from 1970 to diagnosis/reference date (987 cases and 1,180 controls). We estimated overall and source-specific dietary nitrate and nitrite intakes using a food frequency questionnaire (1,037 cases and 1,225 controls). We used unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI). We evaluated interactions with factors that may affect N-nitroso compound formation (i.e., red meat, vitamin C, smoking), and with water intake. RESULTS:Average drinking water nitrate concentration above the 95th percentile (>2.07 mg/L) compared with the lowest quartile (≤0.21 mg/L) was associated with bladder cancer (OR = 1.5, 95% CI = 0.97, 2.3; P trend = 0.01); the association was similar for average daily drinking water nitrate intake. We observed positive associations for dietary nitrate and nitrite intakes from processed meat (highest versus lowest quintile OR for nitrate = 1.4, 95% CI = 1.0, 2.0; P trend = 0.04; OR for nitrite = 1.5, 95% CI = 1.0, 2.1; P trend = 0.04, respectively), but not other dietary sources. We observed positive interactions between drinking water nitrate and red meat (P-interaction 0.05) and processed red meat (0.07). CONCLUSIONS:Our results suggest the importance of both drinking water and dietary nitrate sources as risk factors for bladder cancer.
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最新影响因子:4.86 | 期刊ISSN:1044-3983 | CiteScore:3.31 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1990 |
自引率:7.00% | 研究方向:医学-公共卫生、环境卫生与职业卫生 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal guides epidemiologists, public health investigators, and health professionals (physicians, nurses, dentists, pharmacists) to what's new and important in epidemiological research, including the latest principles and methods of data analysis. Encouraging contributions that challenge hardened ideas and alert the scientific community to new developments, the journal has recently reported on such topics as mortality among cellular telephone customers; caffeine consumption and spontaneous abortion; and NSAIDs and breast cancer.
该杂志指导流行病学家、公共卫生调查人员和卫生专业人员(医生、护士、牙医、药剂师)了解流行病学研究的最新和重要内容,包括最新的数据分析原则和方法。《科学》杂志最近就手机用户的死亡率等问题发表了一篇报道,鼓励那些挑战僵化观念、提醒科学界注意新进展的贡献;咖啡因摄入和自然流产;非甾体抗炎药和乳腺癌。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH(公共、环境和职业卫生) 1区 |
3/157 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
102 | 98 | 4 |
引文计数(2018)
文献(2015-2017)
1805次引用
546篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Epidemiology
|
#24/87
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研究方向:医学-计算机:跨学科应用
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