发表一篇学和医学成像类SCI论文
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Abstract:
:Hemocytes in shrimp play important roles in innate immune responses against pathogens. Although three types of hemocytes including hyalinocytes, semi-granulocytes and granulocytes were identified based on their morphological characters in penaeid shrimp, knowledge about the molecular basis of their functions in the immunity is still very limited. In the present study, three subpopulations of hemocytes were firstly separated by Percoll gradient centrifugation, and their transcriptomes were analyzed. The data showed that significantly differential gene expression patterns existed in different types of hemocytes. The genes encoding phagocytic receptors, lectins and actin cytoskeleton involved in phagocytosis were highly expressed in hyalinocytes, while genes involved in the humoral immunity signaling pathways were highly expressed in semi-granulocytes, and genes encoding prophenoloxidase (proPO)-activating enzyme and serine proteases involved in proPO system activation were highly expressed in granulocytes. Further flow cytometry analysis indicated that hyalinocytes were the main hemocytes subpopulation responsible for ingesting foreign fluorescent beads, and this ingestion process mainly depends on the endocytic way of macropinocytosis. These data provide valuable information for understanding the molecular basis of distinct shrimp hemocytes subpopulations of shrimp in cellular and humoral immunity.
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最新影响因子:3.605 | 期刊ISSN:0145-305X | CiteScore:3.09 |
出版周期:Monthly | 是否OA:YES | 出版年份:1977 |
期刊官方网址:http://www.journals.elsevier.com/developmental-and-comparative-immunology/
期刊投稿地址:http://ees.elsevier.com/dci/
自引率:18.70% | 研究方向:医学-动物学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Official Journal of the International Society of Developmental and Comparative Immunology Developmental and Comparative Immunology (DCI) is an international journal that publishes articles describing original research in all areas of immunology, including comparative aspects of immunity and the evolution and development of the immune system. Manuscripts describing studies of immune systems in both vertebrates and invertebrates are welcome. All levels of immunological investigations are appropriate: organismal, cellular, biochemical and molecular genetics, extending to such fields as aging of the immune system, interaction between the immune and neuroendocrine system and intestinal immunity.
国际发展与比较免疫学学会的官方期刊 发育与比较免疫学(DCI)是一份国际期刊,发表文章描述免疫学各个领域的原始研究,包括免疫的比较方面和免疫系统的进化与发展。描述脊椎动物和无脊椎动物免疫系统研究的手稿是受欢迎的。所有层次的免疫学研究都是适当的:机体、细胞、生化和分子遗传学,延伸到免疫系统老化、免疫和神经内分泌系统相互作用以及肠道免疫等领域。
大类(学科) | 小类(学科) | 学科排名 |
生物 |
FISHERIES (渔业) 2区 VETERINARY SCIENCES (兽医学) 4区 ZOOLOGY (动物学) 2区 IMMUNOLOGY (免疫学) |
6/51 86/155 11/167 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
272 | 271 | 1 |
引文计数(2018)
文献(2015-2017)
2130次引用
690篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Immunology and Microbiology
小类(学科):Immunology
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#76/193
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2 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Developmental Biology
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#26/76
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影响因子:3.241
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影响因子:1.723
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影响因子:1.345
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影响因子:1.536
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研究方向:医学-整形外科
发表一篇学和医学成像类SCI论文
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