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  • Salivation features depending on gender identity of patients

    作者:Irina M.Makeeva;Mikhail T.Alexandrov;Tan Hui-ping;Evgeniy V.Pashkov;Tatiana V.Budina;Edita G.Margaryan

    Objective To study the salivation features depending on gender identity of patients currently is of great interest because homeostasis in the oral cavity may change under the influence of social lifestyle,psychology and physiology of patient's gender.Given this,the study of the most important biological environment of the organism is relevant in different physiological stages of life.The aim of our study is to evaluate the characteristics of salivation depending on gender and sexual identity of patients,taking into account age and physiological periods of life.Methods One hundred and seventy-five people,115 women and 60 men aged from 18 up to 75 years participated in the research conducted by us.Carried out dental inspection of patients,carried out questioning according to Fox's test for identification of existence or lack of a kserostomiya and also carried out collecting the mixed saliva at rest.Results Our results from people requested dental care revealed that there were more women with xerostomia than men and their symptom intensity was stronger.The frequency of manifestation of xerostomia was associated with physiological periods of their lives,with greater emotionality and exposure to stresses,and also with long medication intake.Men were less analyzing the state of their health and noted better stress resistance to a different life situations.Xerostomia was found in them in the case of comorbidity,excessive consumption of sugar rich food and drinks,and less frequently as a result of stress.Conclusion For all patients suffering from false xerostomia were recommended the use of a moisturizing line "Kin Hydrate" to relieve the state of dryness in the mouth,as well as more thorough individual hygiene and intensive supervision by a dentist.The data collected require more careful attention of doctors to prevention of dental diseases,especially in vulnerable physiological periods of life,and changing lifestyle factors and social roles of men and women in today's society must be taken into account in the formation of prevention,treatment and dispensary observation at different levels of organization in the health care system.

  • 作者:

    Xerostomia is a severe side effect of radiation therapy in head and neck cancer patients. To date, no satisfactory treatment option has been established. Because mesenchymal stem cells (MSCs) have been identified as a potential treatment modality, we aimed to evaluate stem cell distribution following intravenous and intraglandular injections using a surgical model of salivary gland damage and to analyse the effects of MSC injections on the recruitment of immune cells. The submandibular gland ducts of rats were surgically ligated. Syngeneic adult MSCs were isolated, immortalised by simian virus 40 (SV40) large T antigen and characterized by flow cytometry. MSCs were injected intravenously and intraglandularly. After 1, 3 and 7 days, the organs of interest were analysed for stem cell recruitment. Inflammation was analysed by immunohistochemical staining. We were able to demonstrate that, after intravenous injection, MSCs were recruited to normal and damaged submandibular glands on days 1, 3 and 7. Unexpectedly, stem cells were recruited to ligated and non-ligated glands in a comparable manner. After intraglandular injection of MSCs into ligated glands, the presence of MSCs, leucocytes and macrophages was enhanced, compared to intravenous injection of stem cells. Our data suggest that injected MSCs were retained within the inflamed glands, could become activated and subsequently recruited leucocytes to the sites of tissue damage.

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